纳他霉素 [游霉素, 匹马霉素]，Pimaricin [Natamycin]；from Streptomyces chattanoogensis, ≥80% (HPLC)

图片 纳他霉素 [游霉素, 匹马霉素]，Pimaricin [Natamycin]；from Streptomyces chattanoogensis, ≥80% (HPLC)
别名：纳他霉素标准品；匹马霉素标准品；纳他菌素；匹马菌素；那他霉素；纳塔霉素；匹马力星；Pimaricin, Streptomyces chattanoogensis

Empirical Formula (Hill Notation): C33H47NO13 CAS号: 7681-93-8 分子量: 665.73 EC 号: 231-683-5 MDL编号: MFCD00135085 PubChem化学物质编号: 329754196 E编号: E235 NACRES: NA.24
制造商品牌: 西格玛 Sigma-Aldrich , 色谱科 Supelco
货号（SKU）: 32417
CAS号: 7681-93-8
MDL号: MFCD00135085
签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √

说明

纳他霉素是一种多烯类抗生素，通常用作抗真菌剂，因为它缺乏耐药性，具有广泛的活性。然而，它的作用模式尚不清楚，直接结合和等温滴定量热法研究表明，纳他霉素与模型膜中存在的麦角甾醇特异性结合。
纳他霉素对霉菌和酵母菌都有活性。它在食品工业中用作杀菌剂和抗生素防腐剂。
纳他霉素可作为分析参考标准，用于使用高性能液相色谱法（HPLC-ESI-HR-MS）和反相高效液相色谱串联质谱技术（UHPLC-MS/MS）对葡萄酒样品中的分析物进行定量。

一般描述

Natamycin is a polyene antibiotic that generally finds application as an antifungal agent as it lacks development of resistance and has a broad spectrum of activity. However, its mode of action is yet unclear, direct binding and isothermal titration calorimetry studies has revealed that natamycin binds specifically to ergosterol present in model membranes.
Natamycin shows activity against both molds and yeasts. It finds applications as a fungicidal and antibiotic preservative in the food industry.
 

应用

Natamycin may be used as an analytical reference standard for the quantification of the analyte in wine samples using high-performance liquid chromatography coupled to electrospray ionization in positive mode high resolution mass spectrometry (HPLC-ESI-HR-MS) and reversed-phase high-performance liquid chromatography-tandem mass spectrometry technique (UHPLC-MS/MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
 

生化/生理作用

与麦角固醇特异性结合并阻止真菌生长的抗真菌多烯大环内脂。但不同于制霉菌素和菲律宾菌素不同，那他霉素不会改变细胞质膜的渗透性
 

法律信息

VETRANAL is a registered trademark of Sigma-Aldrich Chemie GmbH
 
 

属性

等级

analytical standard

质量水平

100

产品线

VETRANAL®

保质期

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

cleaning products
cosmetics
food and beverages
personal care

格式

neat

储存温度

2-8°C

SMILES string

C[C@@H]1C\C=C\C=C\C=C\C=C\[C@@H](C[C@@H]2O[C@](O)(C[C@@H](O)C[C@H]3O[C@@H]3\C=C\C(=O)O1)C[C@H](O)[C@H]2C(O)=O)O[C@@H]4O[C@H](C)[C@@H](O)[C@H](N)[C@@H]4O

InChI

1S/C33H47NO13/c1-18-10-8-6-4-3-5-7-9-11-21(45-32-30(39)28(34)29(38)19(2)44-32)15-25-27(31(40)41)22(36)17-33(42,47-25)16-20(35)14-24-23(46-24)12-13-26(37)43-18/h3-9,11-13,18-25,27-30,32,35-36,38-39,42H,10,14-17,34H2,1-2H3,(H,40,41)/b4-3+,7-5+,8-6+,11-9+,13-12+/t18-,19-,20+,21+,22+,23-,24-,25+,27-,28+,29-,30+,32+,33-/m1/s1

InChI key

NCXMLFZGDNKEPB-FFPOYIOWSA-N

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 30 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 30
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