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红霉素,Erythromycin;EPA 1694, USP/NF, tested according to Ph. Eur.

别名:E-Mycin;Erythrocin;红丝菌素;艾狄密斯;阿达霉素;福爱力;红丝霉素;威霉素;新红康;Ilotycin;Ermycin

Empirical Formula (Hill Notation): C37H67NO13 CAS号: 114-07-8 分子量: 733.93 Beilstein: 75279 EC 号: 204-040-1 MDL编号: MFCD00084654 PubChem化学物质编号: 329756889 NACRES: NA.76
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): 45674
CAS号: 114-07-8
MDL号: MFCD00084654
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¥3,350.00

说明

化学结构:大环内酯
红霉素是一种抗生素,由某些红链霉菌菌株生长产生。本品主要由红霉素A和少量红霉素B和C组成,建议浓度为100 mg/L。浓度在50至200mg/L之间也被证明对控制细菌生长有效。红霉素已被用作胃动素受体激动剂,在体外阻断人气道中的呼吸糖缀合物分泌††,并用于选择质粒治愈和重组乳酸乳球菌MG1363菌株。

一般描述

Chemical structure: macrolide
 

应用

Erythromycin is an antibiotic produced by growth of certain strains of Streptomyces erythreus. This product is composed largely of erythromycin A with small amounts of erythromycins B and C and is recommended for concentration at 100 mg/L. Concentrations between 50 and 200 mg/L have also proven effective in controlling bacterial growth. Erythromycin has been used as a motilin receptor agonist, to block respiratory glycoconjugate secretion in human airways in vitro††, and for selecting plasmid-cured and recombinant lactococcus lactis MG1363 strains.
 

生化/生理作用

作用机制: 红霉素通过在转肽步骤中抑制延伸起作用,特别是通过结合细菌70S rRNA复合物的50S亚单位来抑制氨酰从A位点到P位点的易位。
抗菌谱:该产品可以抗革兰氏阴性和革兰氏阳性细菌。
 

注意

This product is stable in solution at 37°C for 3 days. Stock solutions should be stored at 2-8°C.
 

制备说明

This product is soluble in water at 2 mg/mL, with a 0.067% solution in water yielding a pH of 8.0-10.5. It is also soluble in ethanol at 50 mg/mL, yielding a clear, colorless to faint yellow solution. It is freely soluble in alcohol, acetone, chloroform, acetonitrile and ethyl acetate but forms salts with acids. All solutions should be protected from light.
 

其他说明

Keep container tightly closed in a dry and well-ventilated place.
 
 

属性

Agency

EPA 1694
USP/NF
tested according to Ph. Eur.

质量水平

200

形式

solid

颜色

white to faint yellow

溶解性

H2O: soluble 2 mg/mL
acetone: freely soluble
acetonitrile: freely soluble
alcohol: soluble
amyl acetate: moderately soluble
chloroform: soluble
diethyl ether: soluble
ethyl acetate: freely soluble

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria

application(s)

environmental

作用机制

protein synthesis | interferes

SMILES string

CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O

InChI

1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1

InChI key

ULGZDMOVFRHVEP-RWJQBGPGSA-N

Gene Information

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type N95 (US)

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16
商品标签 [tags]