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红霉素,Erythromycin;BioReagent, suitable for cell culture, ≥850 μg per mg

别名:E-Mycin;Erythrocin;红丝菌素;艾狄密斯;阿达霉素;福爱力;红丝霉素;威霉素;新红康;Ilotycin;Ermycin

CAS号 114-07-8 经验分子式(希尔表示法) C37H67NO13 分子量 733.93 Beilstein/REAXYS Number 75279 EINECS 编号 204-040-1 MDL number MFCD00084654 PubChem Substance ID 24894612 NACRES NA.76
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): E5389
CAS号: 114-07-8
MDL号: MFCD00084654
增值税发票 √ 免费送货 √ 订货电话:010-68689484
¥133.48

产品描述

General description

Chemical structure: macrolide

Erythromycin is an antibiotic produced by growth of certain strains of Streptomyces erythreus. This product is composed largely of erythromycin A with small amounts of erythromycins B and C and is recommended for concentration at 100 mg/L. Concentrations between 50 and 200 mg/L have also proven effective in controlling bacterial growth. Erythromycin has been used as a motilin receptor agonist, to block respiratory glycoconjugate secretion in human airways in vitro, and for selecting plasmid-cured and recombinant lactococcus lactis MG1363 strains.

Application

Erythromycin has been used:
• as a supplement for nutrient broth medium for culturing green fluorescent protein (GFP)- expressing E. coli[1]
• as a model drug to determine small intestinal (SMI) microtissue viability using the MTT assay{254
• as an antibiotic to study the treatment strategies of chronic infections[2]

包装

1, 5 g in poly bottle

Biochem/physiol Actions

作用机制: 红霉素通过在转肽步骤中抑制延伸起作用,特别是通过结合细菌70S rRNA复合物的50S亚单位来抑制氨酰从A位点到P位点的易位。

抗菌谱:该产品可以抗革兰氏阴性和革兰氏阳性细菌。

Caution

This product is stable in solution at 37°C for 3 days. Stock solutions should be stored at 2-8°C.

Preparation Note

This product is soluble in water at 2 mg/mL, with a 0.067% solution in water yielding a pH of 8.0-10.5. It is also soluble in ethanol at 50 mg/mL, yielding a clear, colorless to faint yellow solution. It is freely soluble in alcohol, acetone, chloroform, acetonitrile and ethyl acetate but forms salts with acids. All solutions should be protected from light.

性质

Quality Level200
product lineBioReagent
formpowder
potency≥850 μg per mg
application(s)cell culture | mammalian: suitable
impurities≤0.1 EU/mg endotoxin
colorwhite
mp133 °C
solubility2 M HCl: 50 mg/mL (Stock solutions should be stored at 2-8 °C. Stable at 37 °C for 3 days.)
ethanol: soluble (Stock solutions should be stored at 2-8 °C. Stable at 37 °C for 3 days.)
Mode of actionprotein synthesis | interferes
antibiotic activity spectrumGram-negative bacteria
Gram-positive bacteria
SMILES stringCC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O
InChI1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1
InChI keyULGZDMOVFRHVEP-RWJQBGPGSA-N
Gene Informationhuman ... ABCB1(5243), CYP3A4(1576), MLNR(2862)
mouse ... Abcb1a(18671), Abcb1b(18669)


安全信息

个人防护装备 EyeshieldsGlovestype N95 (US)
RIDADR NONH for all modes of transport
WGK德国 WGK 3
RTECS KF437500
商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16
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