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米托胍腙，Mitoguazone [MGBG]；≥99.0% (HPLC)

图片 米托胍腙，Mitoguazone [MGBG]；≥99.0% (HPLC)
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别名：MGBG，丙脒腙; 丙双脒腙；丙酮双脒腙；甲基乙二醛双脒基腙；甲基乙二醛—双脒腙，外源鸟嘌呤腙，2,2-(1-Methyl-1,2-ethanediylidene)bishydrazinecarboximidamide，1,1-[(Methylethanediylidene)dinitrilo]diguanidine，Methylglyoxal bis-amidinohydrazone，Methylglyoxal bis-guanylhydrazone，Win-10708-2，NSC-30609(acetate)，NSC-32946(diHCl)，Methyl-GAG，Zyrkamine
制造商品牌: BSZH
货号（SKU）: M193101
CAS号: 459-86-9
签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √
¥1,566.32

产品描述

米托胍腙: Mitoguazone（MGBG），采用北实纵横科学公司“Ultra-Pure”专研磁珠工艺及“萃合”技术多步分级纯化。

 
InChI=1/C5H12N8/c1-3(11-13-5(8)9)2-10-12-4(6)7/h2H,1H3,(H4,6,7,12)(H4,8,9,13)/b10-2+,11-3+
分子式：C5H12N8，分子量：184.2

 

科学应用与参考

 

基于此产品的研发或衍生的药物可被用于治疗成人急性粒细胞白血病和恶性淋巴瘤等。
Company：National Cancer Institute (Originator), Ilex Oncology (Licensee), Sanofi-synthélabo (Licensee)
 Usage：Oncolytic Drugs, Antimetabolites, S-Adenosyl-L-methionine Decarboxylase Inhibitors
 
密度：1.55g/cm3
沸点：436.6°C at 760 mmHg
闪点：217.8°C
蒸汽压：7.99E-08mmHg at 25°C

米托胍腙 MGBG 性质参数

The Hydrazinecarboximidamide,2,2'-(1-methyl-1,2-ethanediylidene)bis-, with the CAS registry number 459-86-9, is also known as N''-{(1E,2E)-2-[(Diaminomethylidene)hydrazono]-1-methylethylidene}carbonohydrazonic diamide. The molecular formula of this chemical is C5H12N8 and molecular weight is 184.2024. What's more, its IUPAC name is 2-[(E)-[(1E)-1-(Diaminomethylidenehydrazinylidene)propan-2-ylidene]amino]guanidine. In addition, it should be stored in condition of cold and dry.

Physical properties about Hydrazinecarboximidamide,2,2'-(1-methyl-1,2-ethanediylidene)bis- are: (1)ACD/LogP: -1.27; (2)#of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): -2.97; (4)ACD/LogD (pH 7.4): -1.56; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 2.46; (9)#H bond acceptors: 8; (10)#H bond donors: 8; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 62.4 Å2; (13)Index of Refraction: 1.692; (14)Molar Refractivity: 45.27 cm3; (15)Molar Volume: 118.1 cm3; (16)Polarizability: 17.94×10-24 cm3; (17)Surface Tension: 74.8 dyne/cm; (18)Density: 1.55 g/cm3; (19)Flash Point: 217.8 °C; (20)Enthalpy of Vaporization: 69.31 kJ/mol; (21)Boiling Point: 436.6 °C at 760 mmHg; (22)Vapour Pressure: 7.99E-08 mmHg at 25 °C.

You can still convert the following datas into molecular structure:
(1) SMILES: N(\N=C\C(=N\N=C(/N)N)C)=C(/N)N
(2) InChI: InChI=1/C5H12N8/c1-3(11-13-5(8)9)2-10-12-4(6)7/h2H,1H3,(H4,6,7,12)(H4,8,9,13)/b10-2+,11-3+
(3) InChIKey: MXWHMTNPTTVWDM-NXOFHUPFBJ

The toxicity data is as follows:

 

OrganismTest TypeRouteReported Dose (Normalized Dose)EffectSource
ratLD50intraperitoneal> 150mg/kg (150mg/kg) Advances in Teratology. Vol. 3, Pg. 181, 1968.
 
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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