秋水仙素 [秋水仙碱]，Colchicum autumnale [Colchicine]；Calbiochem®, powder, ≥94%

图片 秋水仙素 [秋水仙碱]，Colchicum autumnale [Colchicine]；Calbiochem®, powder, ≥94%
别名：(S)-N-(5,6,7,9-四氢-1,2,3,10-四甲氧基-9-氧苯并[a]庚搭烯-7-基）乙酰胺； (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide

CAS号 64-86-8 经验分子式（希尔表示法） C22H25NO6 分子量 399.44 MDL number MFCD00078484
制造商品牌: 默克 Merck , 西格玛 Sigma-Aldrich
货号（SKU）: 234115
CAS号: 64-86-8
MDL号: MFCD00078484
签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √
¥1,355.80

说明

秋水仙的主要生物碱。 用于细胞分裂研究的有丝分裂抑制剂。 破坏微管并抑制微管蛋白聚合。 诱导嗜铬细胞瘤 (PC12) 细胞和小脑颗粒细胞凋亡。
有丝分裂抑制剂，可用于细胞分裂研究。 破坏微管并抑制微管蛋白聚合。 诱导 PC12 细胞和小脑颗粒细胞凋亡。

一般描述

Major alkaloid of Colchicum autumnale. Inhibitor of mitosis used in cell division studies. Disrupts microtubules and inhibits tubulin polymerization. Induces apoptosis in pheochromocytoma (PC12) cells and in cerebellar granule cells.
Inhibitor of mitosis that is useful in cell division studies. Disrupts microtubules and inhibits tubulin polymerization. Induces apoptosis in PC12 cells and in cerebellar granule cells.
 

生化/生理作用

Primary Target
Inhibitor of mitosis
Product does not compete with ATP.
Reversible: no
Cell permeable: no
 

警告

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)
 

其他说明

Bonfoco, E., et al. 1995. Exp. Cell Res.218, 189.
Lindenboim, L., et al. 1995. J. Neurochem.64, 1054.
Leung, M.F., and Sartorelli, A.C. 1992. Leuk. Res.16, 929.
Santell, L. 1992. Exp. Cell Res. 201, 358.
Salmon, E.D., et al. 1984. J. Cell Biol.99, 1066.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
 

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
 
 

属性

质量水平

100

测定

≥94% (HPLC)

形式

powder

manufacturer/tradename

Calbiochem®

储存条件

OK to freeze
protect from light

颜色

yellow to off-white

溶解性

ethanol: 10 mg/mL
water: soluble

运输

ambient

储存温度

10-30°C

InChI

1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1

InChI key

IAKHMKGGTNLKSZ-INIZCTEOSA-N

 

安全信息

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险声明

H300 - H340

危险分类

Acute Tox. 1 Oral - Muta. 1B

储存分类代码

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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