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福沙吡坦二甲葡胺,Fosaprepitant dimeglumine;≥98% (HPLC)

别名:MK0517;1-Deoxy-1(methylamino)-D-glucitol[3-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4-triazol-1-yl]phosphonate (2:1) (salt), L-758,298, MK-0517, [3-{[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl] ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl}-5-oxo- 2H-1,2,4-triazol-1-yl]phosphonic acid

CAS号 265121-04-8 经验分子式(希尔表示法) C23H22F7N4O6P · C14H34N2O10 分子量 1004.83 NACRES NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML2228
CAS号: 265121-04-8
MDL号: MFCD23102059
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¥895.04

产品描述

一种NK1受体(P物质及神经激肽-1受体)拮抗剂,它是止吐药物的水溶性前药。

Biochem/physiol Actions

Fosaprepitant dimeglumine is a Substance P/neurokinin-1 (NK1) receptor antagonist. It is a water soluble prodrug of the antiemetic drug aprepitant.

Fosaprepitant二甲双胍是P /神经激肽-1(NK1)物质的拮抗剂。 它是止吐药aprepitant的水溶性前药。

性质

assay  ≥98% (HPLC)
form  powder
optical activity  [α]/D +27 to +34°, c = 0.5 in methanol
storage condition  desiccated
color  white to beige
solubility  H2O: 2 mg/mL, clear
shipped in  wet ice
storage temp.  −20°C
SMILES string  FC1=CC=C([C@@H]2N(CCO[C@@H]2O[C@@H](C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C)CC(NC4=O)=NN4P(O)(O)=O)C=C1.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O


安全信息

RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32