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碳酸酐酶同工酶II来源于牛红细胞,Carbonic Anhydrase Isozyme II from bovine erythrocytes;lyophilized powder, ≥2,000 W-A units/mg protein

别名:碳酸酐酶II;碳酸盐脱水酶;碳酸水解酶;Carbonate Dehydratase, Carbonic Anhydrase II, Carbonate Hydrolyase

CAS号: 9001-03-0 EC 号: 4.2.1.1 (BRENDA, IUBMB) EC 号: 232-576-6 MDL编号: MFCD00081467 NACRES: NA.54
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): C3640
CAS号: 9001-03-0
MDL号: MFCD00081467
增值税发票 √ 免费送货 √ 订货电话:010-68689484
€1688.58

说明

碳酸酐酶是一种锌金属酶,分子量约为 30,000 Da。 该酶催化二氧化碳水合为碳酸。 它参与重要的生理和病理过程,例如 pH 值和 CO2 稳态、碳酸氢盐和 CO2 的运输、生物合成反应、骨吸收、钙化和致瘤性。 因此,该酶是抑制剂的重要靶点,在青光眼、癫痫和帕金森病等病理中具有临床应用。 

应用

Carbonic anhydrase from sigma has been used for the analysis of thermodynamic stability of the enzyme. The enzyme has also been used to generate CD4+ T cell lines specific for carbonic anhydrase during the study of autoimmune pancreatitis in rat.
 

生化/生理作用

Carbonic anhydrase is a zinc metalloenzyme that has a molecular weight of approximately 30,000 Da. The enzyme catalyzes the hydration of carbon dioxide to carbonic acid. It is involved in vital physiological and pathological processes such as pH and CO2 homeostasis, transport of bicarbonate and CO2, biosynthetic reactions, bone resorption, calcification, and tumorigenicity. Therefore, this enzyme is an important target for inhibitors with clinical applications in pathologies such as glaucoma, epilepsy and Parkinson′s disease.
 

单位定义

One Wilbur-Anderson (W-A) unit will cause the pH of a 0.02 M Trizma buffer to drop from 8.3 to 6.3 per min at 0 °C. (One W-A unit is essentially equivalent to one Roughton-Booth unit.)

 

属性

形式

lyophilized powder

质量水平

200

specific activity

≥2,000 W-A units/mg protein

pI 

~5.4

储存温度

−20°C

 

安全信息

个人防护装备

Eyeshields, Gloves, type N95 (US)

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 55 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 8 | 香港与北京 ≥ 10