碘代乙酰胺 [碘乙酰胺]，Iodoacetamide；BioUltra, ≥99% (NMR)

图片 碘代乙酰胺 [碘乙酰胺]，Iodoacetamide；BioUltra, ≥99% (NMR)
别名：2-碘乙酰胺；2-Iodoacetamide；Monoiodoacetamide；线性分子式: ICH2CONH2 CAS号: 144-48-9 分子量: 184.96 Beilstein: 1739080 EC 号: 205-630-1 MDL编号: MFCD00008028 PubChem化学物质编号: 24278486 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: I1149
CAS号: 144-48-9
MDL号: MFCD00008028
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说明

碘乙酰胺（IAA）因其不可逆地抑制糖酵解酶甘油醛-3-磷酸脱氢酶（GAPDH）的能力而被用于抑制糖酵分解。IAA用于研究半胱氨酸残基在酶催化和脑细胞转运过程中的作用。它可以与巯基乙醇和谷胱甘肽等低分子量硫醇化合物反应。IAN还可能阻断菠萝蛋白酶、组织蛋白酶C、梭菌蛋白酶和羧肽酶P等酶。
碘乙酰胺作为肽测序中半胱氨酸残基的烷基化试剂。它是一种不可逆的酶抑制剂，在活性位点具有半胱氨酸。它与组氨酸残基的反应要慢得多，但这种活性是抑制核糖核酸酶的原因。

应用

Iodoacetamide has been used:
  • in protein digestion for proteomic analysis
  • to alkylate protein samples
  • in the denaturation of cow′s milk allergens, β-lactoglobulin (BLG) and α-lactalbumin (ALA)

生化/生理作用

Iodoacetamide (IAA) is used to inhibit glycolysis due to its ability to irreversibly inhibit the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH). IAA is used to investigate the role of cysteine residues in enzyme catalysis and the brain cell transport process. It can react with low molecular weight thiol compounds like mercaptoethanol and glutathione. IAN may also block enzymes like bromelain, cathepsin C, clostripain, and carboxypeptidase P.
Iodoacetamide acts as an alkylating reagent for cysteine residues in peptide sequencing. It is an irreversible inhibitor of enzymes with cysteine at the active site. It reacts much more slowly with histidine residues, but that activity is responsible for inhibiting ribonuclease.
 
 

属性

生物来源

synthetic (organic)

质量水平

300

产品线

BioUltra

测定

≥99% (NMR)

形式

powder

杂质

≤0.0005% Phosphorus (P)
≤0.1% Insoluble matter

mp

92-95 °C (lit.)

溶解性

H2O: 0.5 M, clear, colorless

痕量阴离子

chloride (Cl-): ≤0.05%
sulfate (SO42-): ≤0.05%

痕量阳离子

Al: ≤0.0005%
Ca: ≤0.0005%
Cu: ≤0.0005%
Fe: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
NH4+: ≤0.05%
Na: ≤0.05%
Pb: ≤0.001%
Zn: ≤0.0005%

储存温度

2-8°C

SMILES string

NC(=O)CI

InChI

1S/C2H4INO/c3-1-2(4)5/h1H2,(H2,4,5)

InChI key

PGLTVOMIXTUURA-UHFFFAOYSA-N

 

安全信息

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 3 Oral - Aquatic Chronic 4 - Resp. Sens. 1 - Skin Sens. 1

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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