硫酸鱼精蛋白 [鲑鱼精蛋白硫酸盐]，Protamine sulfate salt from salmon；Grade X, amorphous powder

General description

Protamine are proteins rich in cysteine and arginine.^[4] It possesses many phosphorylation sites.^[5] It is found to be localized to the sperm head.^[6]

Application

Protamine sulfate salt from salmon has been used:
• in the pretreament of cells to study its effect on respiratory syncytial virus infection^[1]
• in lentivirus production^[2]
• to derivatize it into a diazeniumdiolate NO donor^[3]

与由Esterquat-1组成的具有可比性的固体脂质纳米颗粒（SLN）相比，SLN形式的鱼精蛋白可更有效地促进质粒DNA的转染，而且细胞毒性更低。

可用于从蛋白样品中去除DNA或用于纯化DNA结合蛋白。可用作逆转录病毒介导的基因转移中聚凝胺的替代物。

与由Esterquat-1组成的具有可比性的固体脂质纳米颗粒（SLN）相比，SLN形式的鱼精蛋白可更有效地促进质粒DNA的转染，而且细胞毒性更低。

包装

1, 5, 10, 25, 100 g in poly bottle

Biochem/physiol Actions

硫酸鱼精蛋白是一种可与 DNA 结合并产生沉淀的小阳离子蛋白。它能中和肝素的抗凝血活性，还可抑制脂蛋白脂肪酶。