硫酸葡聚糖钠盐来源于明串珠菌属，Dextran sulfate sodium salt from Leuconostoc spp.；average mol wt 9,000-20,000

Dextran sulfate sodium is a natural polymer of α-1,6-D-glucopyranose. It is a hydrophilic, biodegradable, and biocompatible polyanionic polymer. This highly branched polysaccharide has 1,6 and 1,4 glycosidic linkages, consisting of 2.3 sulfate groups per glucosyl unit.

 

Dextran sulfate sodium salt from Leuconostoc spp. has been used:

• to evaluate the participation of sulfated glycans on the interaction of recombinant human proacrosin/acrosin with zona pellucida (ZP) glycoproteins
• to inject into the vitreous cavity of embryonic day five chick embryos to assess the eye size and to study its impact on cell proliferation in the retina
• to test the structural specificity of binding of TNF-stimulated gene 6 (TSG-6) to immobilized hyaluronan (HA)

Dextran sulfate may exhibit anti-coagulant and antiviral properties. It may also help to lower cholesterol levels. It is extensively used as a plasma volume expander and fibrinolytic in the medical field. Dextran sulfate can also be used as a cross-linker for chitosan (CH).