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硫酸新霉素,Neomycin trisulfate salt hydrate;meets USP testing specifications, powder, ≥600 μg neomycin per mg (Dried basis)

别名:新霉素三硫酸盐水合物;新霉素硫酸盐;硫酸新链丝菌素;Neomin sulfate; Mycifradin sulfate;Neomycin trisulfate salt hydrate

CAS号 1405-10-3 经验分子式(希尔表示法) C23H46N6O13 · 3H2SO4 · xH2O 分子量 908.88 (anhydrous basis) EINECS 编号 215-773-1 PubChem Substance ID 24897730 NACRES NA.76
货号(SKU): N5285
CAS号: 1405-10-3
MDL号: MFCD00077833
增值税发票 √ 免费货运 [顺丰 联邦] √
¥866.00

产品描述

General description

Chemical structure: aminoglycoside

包装

25, 100 g in glass bottle

Application

Neomycin Trisulfate is produced by Streptomyces containing a minimum of 85% neomycin B. It has been used as a selection agent for prokaryotic cells transformed using the neo selectable marker gene, and to study ototoxic side effects of antibiotics, platelet-derived growth factor responses in certain fibroblasts, and extraction of Nuclear Phosphatidylinositol 4,5-Bisphosphate-Interacting Proteins. It is recommended for use in cell culture applications at 50 mg/L.

Biochem/physiol Actions

作用方式:该产品通过和30S以及50S亚基结合,引起错编,抑制蛋白质合成过程的起始和延长。 新霉素也可阻断电压敏感的Ca2+ 通道,而不会影响神经元中Na+/Ca2+逆向转运蛋白。

抗菌谱:新霉素能够作用于革兰氏阳性和阴性细菌。

Caution

Stock solutions should be filter sterilized and stored at 2-8°C, and are stable at 37°C for 5 days. A 1 mg/mL neomycin solution in .1 M phosphate buffer, pH 8.0 should be used within 14 days when stored at 0-5°C. Solutions should be protected from light or moisture.

Preparation Note

Neomycin sulfate is soluble in H2O at 50 mg/mL, yielding a clear solution.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place

性质

Quality Level200
formpowder
solubilityH2O: 50 mg/mL (Stock solutions should be filter sterilized and stored at 2-8 °C. Stable at 37 °C for 5 days.)
suitabilitymeets USP testing specifications
Featured IndustryPharmaceutical (small molecule)
Mode of actionprotein synthesis | interferes
antibiotic activity spectrumGram-negative bacteria
Gram-positive bacteria
SMILES stringO.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)[C@@H](O[C@@H]2CO)O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]4O[C@H](CN)[C@@H](O)[C@H](O)[C@H]4N)C(N)[C@@H](O)[C@@H]1O
InChI1S/C23H46N6O13.3H2O4S.H2O/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;3*1-5(2,3)4;/h5-23,30-36H,1-4,24-29H2;3*(H2,1,2,3,4);1H2/t5-,6+,7-,8+,9-,10-,11?,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;;;;/m1..../s1
InChI keyWHAGUNPVKDUVFV-QGTTWHFQSA-N


安全信息

符号
GHS08  GHS08
信号词 Danger
危害声明 H317 - H334
警示性声明 P280 - P302 + P352
危害码 (欧洲) Xi
风险声明 (欧洲) 42/43
安全声明 (欧洲) 22-36/37-45
RIDADR NONH for all modes of transport
WGK德国 WGK 3
RTECS QO4375000
商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 190 | 欧洲Eur. ≥ 66 | 東京Tokyo ≥ 82 | 香港与北京 ≥ 55