过滤
关闭导航

硫酸新霉素,Neomycin trisulfate salt hydrate;meets USP testing specifications, powder, ≥600 μg neomycin per mg (Dried basis)

别名:新霉素三硫酸盐水合物;新霉素硫酸盐;硫酸新链丝菌素;Neomin sulfate; Mycifradin sulfate;Neomycin trisulfate salt hydrate

Empirical Formula (Hill Notation): C23H46N6O13 · 3H2SO4 · xH2O CAS号: 1405-10-3 分子量: 908.88 (anhydrous basis) EC 号: 215-773-1 PubChem化学物质编号: 24897730 NACRES: NA.76
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): N5285
CAS号: 1405-10-3
MDL号: MFCD00077833
增值税发票 √ 技术支持 √ 质量保障 √ 电话:13910327035
¥912.00

说明

化学结构:氨基糖苷
三硫酸新霉素是由含有至少85%新霉素B的链霉菌产生的。它已被用作使用新选择标记基因转化的原核细胞的选择剂,并用于研究抗生素的耳毒性副作用、某些成纤维细胞中血小板衍生生长因子的反应、,以及核磷脂酰肌醇4,5-双磷酸盐相互作用蛋白的提取。建议在50 mg/L的细胞培养应用中使用。

一般描述

Chemical structure: aminoglycoside
 

应用

Neomycin Trisulfate is produced by Streptomyces containing a minimum of 85% neomycin B. It has been used as a selection agent for prokaryotic cells transformed using the neo selectable marker gene, and to study ototoxic side effects of antibiotics, platelet-derived growth factor responses in certain fibroblasts, and extraction of Nuclear Phosphatidylinositol 4,5-Bisphosphate-Interacting Proteins. It is recommended for use in cell culture applications at 50 mg/L.
 

生化/生理作用

作用方式:该产品通过和30S以及50S亚基结合,引起错编,抑制蛋白质合成过程的起始和延长。 新霉素也可阻断电压敏感的Ca2+ 通道,而不会影响神经元中Na+/Ca2+逆向转运蛋白。

抗菌谱:新霉素能够作用于革兰氏阳性和阴性细菌。
 

注意

Stock solutions should be filter sterilized and stored at 2-8°C, and are stable at 37°C for 5 days. A 1 mg/mL neomycin solution in .1 M phosphate buffer, pH 8.0 should be used within 14 days when stored at 0-5°C. Solutions should be protected from light or moisture.
 

制备说明

Neomycin sulfate is soluble in H2O at 50 mg/mL, yielding a clear solution.
 

其他说明

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place
 
 

属性

Agency

USP/NF
meets USP testing specifications

质量水平

200

形式

powder

溶解性

H2O: 50 mg/mL (Stock solutions should be filter sterilized and stored at 2-8 °C. Stable at 37 °C for 5 days.)

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria

application(s)

pharmaceutical (small molecule)

作用机制

protein synthesis | interferes

SMILES string

O.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O.NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)[C@@H](O[C@@H]2CO)O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]4O[C@H](CN)[C@@H](O)[C@H](O)[C@H]4N)C(N)[C@@H](O)[C@@H]1O

InChI

1S/C23H46N6O13.3H2O4S.H2O/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;3*1-5(2,3)4;/h5-23,30-36H,1-4,24-29H2;3*(H2,1,2,3,4);1H2/t5-,6+,7-,8+,9-,10-,11?,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;;;;/m1..../s1

InChI key

WHAGUNPVKDUVFV-QGTTWHFQSA-N

 

安全信息

象形图

Health hazard

警示用语:

Danger

危险声明

预防措施声明

危险分类

Resp. Sens. 1 - Skin Sens. 1

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32