硫酸庆大霉素，Gentamicin sulfate；Pharmaceutical Secondary Standard; Certified Reference Material

图片 硫酸庆大霉素，Gentamicin sulfate；Pharmaceutical Secondary Standard; Certified Reference Material
别名：正泰霉素；庆大霉素硫酸酯；庆大霉素硫酸盐；庆大霉素C；庆大霉素硫酸盐；硫酸艮他霉素；硫酸正泰霉素；硫酸双生霉素；Garamycin；Gentamicin sulfate salt；Gentiomycin C

CAS号: 1405-41-0 EC 号: 215-778-9 MDL编号: MFCD00270181 PubChem化学物质编号: 329823100 NACRES: NA.24
制造商品牌: 西格玛 Sigma-Aldrich , 色谱科 Supelco
货号（SKU）: PHR1077
CAS号: 1405-41-0
MDL号: MFCD00270181
签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √

说明

庆大霉素是一种氨基糖苷复合物，由紫色小单孢菌或M。棘孢菌属。用作硫酸盐。有三种成分，每种成分由五个碱性氮组成，每摩尔庆大霉素碱需要五当量硫酸。
这种广谱抗生素广泛用作活性药物成分（API），对革兰氏阳性菌和革兰氏阴性菌都具有治疗潜力。
硫酸庆大霉素可作为药物参考标准，用于使用不同色谱技术定量药物制剂中的分析物。它也被用作细胞培养和分子生物学应用中的选择剂（庆大霉素抗性基因）。本产品推荐使用浓度为50 mg/L。

一般描述

Gentamicin is an aminoglycoside complex produced by fermentation of Micromonospora purpurea or M. echinospora. It is used as the sulfate salt. There are three components, each consisting of five basic nitrogens and requiresing five equivalents of sulfuric acid per mole of gentamicin base.
This broad-spectrum antibiotic, is widely used as an active pharmaceutical ingredient (API) with therapeutic potential against both Gram-positive and Gram-negative bacteria.

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards and pharmacopeia primary standards.
 

应用

Gentamicin Sulfate may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using different chromatography techniques. It is also used as a selection agent (gentamicin-resistance gene) in cell culture and molecular biology applications. This product is recommended for use at 50 mg/L.
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
 

生化/生理作用

作用机制：庆大大霉素通过和30S核糖亚基结合，引起密码子误读，阻碍肽酰转移酶从供体位点转移到受体位点。 庆大霉素通过它与外膜的结合来发挥它对铜绿假单胞菌的杀菌作用，它在外膜上置换天然阳离子，使膜不稳定，并在细胞表面形成孔。

抗菌谱： 包括革兰氏阴性和革兰氏阳性细菌，包括对于四环素，氯霉素，卡那霉素和粘菌素，某些特定假单胞菌菌株，变形杆菌属，Staphylococcus 和Streptococcus的抗性。
 

注意

Sterile solutions should be stored at 2-8°C. Solutions have also been shown to be stable at room temperature and in boiling aqueous buffers of pH 2-142.
 

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
 

附注

To see an example of a Certificate of Analysis for this material enter LRAB3514 in the slot below. This is an example certificate only and may not be the lot that you receive.
 
 

属性

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to BP 174
traceable to Ph. Eur. G0200000
traceable to USP 1289003

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

-10 to -25°C

SMILES string

O=S(O)(O)=O.O[C@]1(C)[C@@H]([C@@H](O)[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3O[C@@](CC[C@H]3N)([C@@H](C)NC)[H])[C@@H](N)C[C@H]2N)OC1)NC.O[C@]4(C)[C@@H]([C@@H](O)[C@@H](O[C@@H]5[C@@H](O)[C@H](O[C@H]6O[C@@](CC[C@H]6N)([C@@H](C)N)[H])[C@@H](N)C[C@H]5N)OC4)NC.O[

InChI

1S/C21H43N5O7.C20H41N5O7.C19H39N5O7.H2O4S/c1-9(25-3)13-6-5-10(22)19(31-13)32-16-11(23)7-12(24)17(14(16)27)33-20-15(28)18(26-4)21(2,29)8-30-20;1-8(21)12-5-4-9(22)18(30-12)31-15-10(23)6-11(24)16(13(15)26)32-19-14(27)17(25-3)20(2,28)7-29-19;1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17;1-5(2,3)4/h9-20,25-29H,5-8,22-24H2,1-4H3;8-19,25-28H,4-7,21-24H2,1-3H3;8-18,24-27H,3-7,20-23H2,1-2H3;(H2,1,2,3,4)/t9-,10-,11+,12-,13+,14+,15-,16-,17+,18-,19-,20-,21+;8-,9-,10+,11-,12+,13+,14-,15-,16+,17-,18-,19-,20+;8-,9+,10-,11+,12-,13+,14+,15-,16+,17+,18+,19-;/m110./s1

InChI key

RDEIXVOBVLKYNT-HDZPSJEVSA-N

 

安全信息

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H317 - H334

危险分类

Resp. Sens. 1 - Skin Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 2

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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