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硫酸卡那霉素,Kanamycin sulfate from Streptomyces kanamyceticus;meets USP testing specifications, powder, ≥750 μg per mg

别名:卡那霉素硫酸酯来源于卡那霉素链霉菌;卡那霉素A;卡那霉素碱硫酸盐;卡那霉素硫酸盐;Kanamycin A;Kanamycin sulfate salt

CAS号 25389-94-0 经验分子式(希尔表示法) C18H36N4O11 · H2O4S 分子量 582.58 EINECS 编号 246-933-9 MDL number MFCD00070253 PubChem Substance ID 24896209 NACRES NA.76
货号(SKU): K1637
CAS号: 25389-94-0
MDL号: MFCD00070253
增值税发票 √ 免费货运 [顺丰 联邦] √
¥507.00

产品描述

General description

Chemical structure: aminoglycoside

Application

Kanamycin sulfate is a broad spectrum aminoglycoside-antibiotic derived from Streptomyces kanamyceticus. It is used as an additive in culture media for the isolation of group D streptococci on Kanamycin Esculin Azide Agar and for selection of transformed plant cells containing the neomycin phosphotransferase on a kanamycin-medium. Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. It is recommended for use in cell culture applications at 100 μg/mL.

包装

1, 5, 25 g in poly bottle

Biochem/physiol Actions

作用机制:该产品通过与70S核糖体亚基结合,抑制易位并引起错误编码而起作用。

耐药机制:氨基糖苷类修饰酶(包括乙酰转移酶、磷酸转移酶、核苷酸转移酶)可以改变这种抗生素,阻止其与核糖体相互作用。

抗菌谱:硫酸卡那霉素对革兰氏阴性和革兰氏阳性菌以及支原体有效。

Caution

Solutions are stable at 37°C for approximately 5 days. Aqueous stock solutions can be stored at 2-8°C for long term storage.

Preparation Note

Kanamycin sulfate is soluble in water at 50 mg/mL, yielding a clear solution. It is practically insoluble in alcohol, acetone, chloroform, ether and ethyl acetate. A 1% solution in water has a pH of 6.5 to 8.5. Sterile solutions can be prepared by a sterile filtration, through a .2μm filter.

性质

Quality Level300
biological sourceStreptomyces kanamyceticus
formpowder
potency≥750 μg per mg
solubilityH2O: 10-50 mg/mL (As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 5 days.)
suitabilitymeets USP testing specifications
Featured IndustryPharmaceutical (small molecule)
Mode of actionprotein synthesis | interferes
antibiotic activity spectrumGram-negative bacteria
Gram-positive bacteria
mycobacteria
mycoplasma
SMILES stringOS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
InChI1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1
InChI keyOOYGSFOGFJDDHP-KMCOLRRFSA-N


安全信息

符号
GHS08  GHS08
信号词 Danger
危害声明 H360D
警示性声明 P201 - P308 + P313
个人防护装备 EyeshieldsGlovestype N95 (US)
危害码 (欧洲) T
风险声明 (欧洲) 61
安全声明 (欧洲) 53-45
RIDADR NONH for all modes of transport
WGK德国 WGK 2
RTECS NZ3225030
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 190 | 欧洲Eur. ≥ 66 | 東京Tokyo ≥ 82 | 香港与北京 ≥ 55