硫酸卡那霉素，Kanamycin sulfate from Streptomyces kanamyceticus；meets USP testing specifications, powder, ≥750 μg per mg

别名：卡那霉素硫酸酯来源于卡那霉素链霉菌；卡那霉素A；卡那霉素碱硫酸盐；卡那霉素硫酸盐；Kanamycin A；Kanamycin sulfate salt

Empirical Formula (Hill Notation): C18H36N4O11 · H2O4S CAS号: 25389-94-0 分子量: 582.58 EC 号: 246-933-9 MDL编号: MFCD00070253 PubChem化学物质编号: 24896209 NACRES: NA.76

制造商品牌: 西格玛 Sigma-Aldrich

货号（SKU）: K1637

CAS号: 25389-94-0

MDL号: MFCD00070253

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说明

化学结构：氨基糖苷
硫酸卡那霉素是一种广谱氨基糖苷类抗生素，来源于卡那链霉菌。它被用作培养基中的添加剂，用于在卡那霉素-乙酰壳聚糖叠氮琼脂上分离D组链球菌，并用于在卡那霉素培养基上选择含有新霉素磷酸转移酶的转化植物细胞。硫酸卡那霉素也可用作用卡那霉霉素B抗性基因转化的细胞的选择剂。建议在100μg/mL的细胞培养应用中使用。

一般描述

Chemical structure: aminoglycoside

应用

Kanamycin sulfate is a broad spectrum aminoglycoside-antibiotic derived from Streptomyces kanamyceticus. It is used as an additive in culture media for the isolation of group D streptococci on Kanamycin Esculin Azide Agar and for selection of transformed plant cells containing the neomycin phosphotransferase on a kanamycin-medium. Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. It is recommended for use in cell culture applications at 100 μg/mL.

生化/生理作用

作用机制：该产品通过与70S核糖体亚基结合，抑制易位并引起错误编码而起作用。
耐药机制：氨基糖苷类修饰酶（包括乙酰转移酶、磷酸转移酶、核苷酸转移酶）可以改变这种抗生素，阻止其与核糖体相互作用。
抗菌谱：硫酸卡那霉素对革兰氏阴性和革兰氏阳性菌以及支原体有效。

注意

Solutions are stable at 37°C for approximately 5 days. Aqueous stock solutions can be stored at 2-8°C for long term storage.

制备说明

Kanamycin sulfate is soluble in water at 50 mg/mL, yielding a clear solution. It is practically insoluble in alcohol, acetone, chloroform, ether and ethyl acetate. A 1% solution in water has a pH of 6.5 to 8.5. Sterile solutions can be prepared by a sterile filtration, through a .2μm filter.

属性

生物来源

Streptomyces kanamyceticus

质量水平

300

Agency

USP/NF
meets USP testing specifications

形式

powder

效能

≥750 μg per mg

溶解性

H₂O: 10-50 mg/mL (As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 5 days.)

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria
mycobacteria
mycoplasma

application(s)

pharmaceutical (small molecule)

作用机制

protein synthesis | interferes

SMILES string

OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1

InChI key

OOYGSFOGFJDDHP-KMCOLRRFSA-N

安全信息

象形图

GHS08

警示用语：

Danger

危险声明

H360D

预防措施声明

P201 - P308 + P313

危险分类

Repr. 1B

储存分类代码

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 2

个人防护装备

Eyeshields, Gloves, type N95 (US)

商品规格

属性名称	属性值
储存温度 Storage temp.	2-8°C冷藏
全球实时库存 Availability √	美国St. Louis ≥ 50 \| 欧洲Eur. ≥ 12 \| 東京Tokyo ≥ 20 \| 香港与北京 ≥ 50

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