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硫化舒林酸,Sulindac sulfide;≥98% (HPLC), solid

别名:(Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid;(Z)-5-氟-2-甲基-1-对甲硫基亚苄基]茚-3-乙酸

Empirical Formula (Hill Notation): C20H17FO2S CAS号: 32004-67-4 分子量: 340.41 EC 号: 250-892-2 MDL编号: MFCD00869764 PubChem化学物质编号: 24899543 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): S3131
CAS号: 32004-67-4
MDL号: MFCD00869764
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¥1,172.50

说明

人内皮细胞HMEC-1用舒林酸硫化物处理,并通过MTT测定研究对细胞存活的影响。

舒林酸硫化物是一种非甾体抗炎化合物,优先使用COX-1;它是Raf-1的Ras激活抑制剂。它通过CDC25损害Ras上的核苷酸交换,并通过p120GAP加速Ras对GTP的水解。它是舒林酸的活性代谢物。它还被证明通过COX-1和COX-2独立机制抑制生长并诱导人前列腺癌细胞凋亡。舒林酸硫化物是一种具有抗增殖和凋亡作用的镇痛药。它抑制环氧合酶-2在人结肠癌细胞中的表达和活性,并减轻腺瘤性息肉病患者的肿瘤负荷。

应用

Human endothelial cells, HMEC-1 were treated with Sulindac sulfide and the effect on cell survival was studies by MTT assay.[1]
 

生化/生理作用

Sulindac sulfide is a non-steroidal anti-inflammatory compound with a preference for COX-1; it is an inhibitor of Ras activation of Raf-1. It impairs nucleotide exchange on Ras by CDC25 and accelerates Ras hydrolysis of GTP by p120GAP. It is an active metabolite of sulindac. It is also shown to inhibit growth and induce apoptosis in human prostate cancer cells through a COX-1 and COX-2 independent mechanism. Sulindac sulfide is an analgesic that has antiproliferative and apoptotic effects. It inhibits the expression and activity of cyclooxygenase-2 in human colon cancer cells[2][3] and reduces tumor burden in adenomatous polyposis patients.[4]
 
 

属性

测定

≥98% (HPLC)

形式

solid

颜色

yellow

溶解性

DMSO: ≥22 mg/mL

SMILES string

[H]\C(c1ccc(SC)cc1)=C2/C(C)=C(CC(O)=O)c3cc(F)ccc23

InChI

1S/C20H17FO2S/c1-12-17(9-13-3-6-15(24-2)7-4-13)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-

InChI key

LFWHFZJPXXOYNR-MFOYZWKCSA-N

 

安全信息

象形图

Exclamation markHealth hazard

警示用语:

Danger

危险分类

Acute Tox. 4 Oral - Repr. 2 - Resp. Sens. 1 - Skin Sens. 1

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16
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