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知母皂苷元,Sarsasapogenin;≥98%

别名:菝葜皂苷元;番石榴素;Parigenin;(25S)-Spirostan-3β-ol; Empirical Formula (Hill Notation): C27H44O3 CAS号: 126-19-2 分子量: 416.64 EC 号: 204-776-3 MDL编号: MFCD00270414 PubChem化学物质编号: 24899798 NACRES: NA.25
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): S8534
CAS号: 126-19-2
MDL号: MFCD00270414
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说明

Sarsasapogenin 也称为 Sarsagenin 或 Parigenin,是一种甾体皂苷,是知母的主要成分。Sarsasapogenin 已被用作 U-2 OS 细胞的合成皂苷治疗,以测试其在降低骨肉瘤细胞活力和下调 YAP 和 TAZ 蛋白方面的作用。

Sarsasapogenin 是一种众所周知的阿尔茨海默病多靶点定向配体 (MTDL)。 它具有抗炎、抗氧化、抗关节炎、抗哮喘、抗淀粉样蛋白形成、神经保护、抗抑郁和抗癌特性。 SAR 还可以改善 1 型糖尿病大鼠的学习和记忆能力、神经元损失,并预防糖尿病性脑病。 它也是治疗溃疡性结肠炎 (UC) 的治疗靶点。 SAR 作为抗炎剂可改善高脂饮食 (HFD) 喂养小鼠的胰岛素抵抗和脂肪组织炎症。

一般描述

Sarsasapogenin also known as Sarsagenin or Parigenin, is a steroidal saponin and is the main constituent of Anemarrhena asphodeloides Bunge.
 

应用

Sarsasapogenin has been used as a synthetic saponin treatment to U-2 OS cells to test its effects in reducing osteosarcoma cell viability and down-regulating YAP and TAZ proteins.
 

生化/生理作用

Sarsasapogenin is a well-known multi-target directed ligand (MTDL) for Alzheimer′s disease. It elicits anti-inflammatory, antioxidant, anti-arthritis, anti-asthma, anti-amyloidogenic, neuroprotective, anti-depressant, and anti-cancer properties. SAR also improves learning and memory ability, loss of neurons in type-1 diabetic rats and protects against diabetic encephalopathy. It is also a therapeutic target for treating ulcerative colitis (UC). SAR as an anti-inflammatory agent improves insulin resistance and adipose tissue inflammation in high-fat diet (HFD)-fed mice.
 

其他说明

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. S8534.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
 
 

属性

质量水平

200

测定

≥98%

SMILES string

C[C@H]1CC[C@@]2(OC1)O[C@H]3C[C@H]4[C@@H]5CC[C@@H]6C[C@@H](O)CC[C@]6(C)[C@H]5CC[C@]4(C)[C@H]3[C@@H]2C

InChI

1S/C27H44O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h16-24,28H,5-15H2,1-4H3/t16-,17-,18+,19-,20+,21-,22-,23-,24-,25-,26-,27+/m0/s1

InChI key

GMBQZIIUCVWOCD-WWASVFFGSA-N

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type N95 (US)

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 55 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 8 | 香港与北京 ≥ 10
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