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盐酸阿霉素 [盐酸多柔比星],Doxorubicin hydrochloride [DOX];suitable for fluorescence, 98.0-102.0% (HPLC)

别名:阿霉素盐酸盐;多柔比星盐酸盐;羟基柔红霉素盐酸盐;14-羟基柔红霉素;14-羟基正定霉素;羟基正定霉素;亚得利亚霉素;亚德利亚霉素;DOX;Hydroxydaunorubicin hydrochloride

CAS号 25316-40-9 经验分子式(希尔表示法) C27H29NO11 · HCl 分子量 579.98 Beilstein/REAXYS Number 4229251 EINECS 编号 246-818-3 MDL number MFCD00077757 PubChem Substance ID 57650234
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): 44583
CAS号: 25316-40-9
MDL号: MFCD00077757
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HK$1,834.15

产品描述

General description

Chemical structure: tetracycline

Application

Doxorubicin was used to induce apoptosis, and to induce cardiotoxicity in SK-N-MC cells [2][3]. It is used to inhibit macromolecular biosynthesis.

包装

1, 10, 50 mg in glass bottle

Biochem/physiol Actions

Doxorubicin ia an antitumor antibiotic that intercalates DNA and inhibits macromolecular biosynthesis. DNA replication is haulted due to the inhibition of topoisomerase II. It is an inhibitor of reverse transcriptase and RNA polymerase and is an immunosuppressive agent [1].

包装

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

法律信息

Adriamycin 为以下机构的注册商标: RDF Pharmacia & Upjohn S.P.A.

性质

Quality Level200
biological sourcesynthetic
assay98.0-102.0% (HPLC)
formsolid
colororange to dark red
mp216 °C (dec.) (lit.)
solubilityH2O: 50 mg/mL, clear, orange to red
DMSO: soluble
THF: soluble
ethanol: soluble
methanol: soluble
fluorescenceλex 470 nm; λem 585 nm in ethanol
suitabilitysuitable for fluorescence
Mode of actionDNA synthesis | interferes
enzyme | inhibits
antibiotic activity spectrumneoplastics
storage temp.2-8°C
SMILES stringCl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
InChI1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
InChI keyMWWSFMDVAYGXBV-RUELKSSGSA-N
Gene Informationhuman ... TOP2A(7153)


安全信息

符号
信号词 Danger
危害声明 H302-H315-H319-H350
危害码 (欧洲) T,Xi
风险声明 (欧洲) 45-22-36/38
安全声明 (欧洲) 53-45
RIDADR NONH for all modes of transport
WGK德国 3
RTECS QI9295900
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 300 | 欧洲Eur. ≥ 90 | 東京Tokyo ≥ 36 | 香港与北京 ≥ 99
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