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盐酸阿霉素 [盐酸多柔比星]，Doxorubicin hydrochloride [DOX]；suitable for fluorescence, 98.0-102.0% (HPLC)

别名：阿霉素盐酸盐；多柔比星盐酸盐；羟基柔红霉素盐酸盐；14-羟基柔红霉素；14-羟基正定霉素；羟基正定霉素；亚得利亚霉素；亚德利亚霉素；DOX；Hydroxydaunorubicin hydrochloride

CAS号 25316-40-9 经验分子式（希尔表示法） C27H29NO11 · HCl 分子量 579.98 Beilstein/REAXYS Number 4229251 EINECS 编号 246-818-3 MDL number MFCD00077757 PubChem Substance ID 57650234

品牌: 西格玛 Sigma-Aldrich

货号（SKU）: 44583

CAS号: 25316-40-9

MDL号: MFCD00077757

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目录价.SKU-Variant

10mg
250mg [+¥3,181.00]
1g [+¥8,392.00]

¥1,550.00

数量:

产品描述

General description

Chemical structure: tetracycline

Application

Doxorubicin was used to induce apoptosis, and to induce cardiotoxicity in SK-N-MC cells ^[2]^[3]. It is used to inhibit macromolecular biosynthesis.

包装

1, 10, 50 mg in glass bottle

Biochem/physiol Actions

Doxorubicin ia an antitumor antibiotic that intercalates DNA and inhibits macromolecular biosynthesis. DNA replication is haulted due to the inhibition of topoisomerase II. It is an inhibitor of reverse transcriptase and RNA polymerase and is an immunosuppressive agent ^[1].

包装

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

法律信息

Adriamycin 为以下机构的注册商标： RDF Pharmacia & Upjohn S.P.A.

性质

Quality Level	200
biological source	synthetic
assay	98.0-102.0% (HPLC)
form	solid
color	orange to dark red
mp	216 °C (dec.) (lit.)
solubility	H₂O: 50 mg/mL, clear, orange to red
	DMSO: soluble
	THF: soluble
	ethanol: soluble
	methanol: soluble
fluorescence	λ_ex 470 nm; λ_em 585 nm in ethanol
suitability	suitable for fluorescence
Mode of action	DNA synthesis \| interferes
	enzyme \| inhibits
antibiotic activity spectrum	neoplastics
storage temp.	2-8°C
SMILES string	Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
InChI	1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
InChI key	MWWSFMDVAYGXBV-RUELKSSGSA-N
Gene Information	human ... TOP2A(7153)

安全信息

符号

GHS07, GHS08

信号词 Danger

危害声明 H302-H315-H319-H350

警示性声明 P201-P280-P301 + P312 + P330-P305 + P351 + P338-P308 + P313

个人防护装备 Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

危害码 (欧洲) T,Xi

风险声明 (欧洲) 45-22-36/38

安全声明 (欧洲) 53-45

RIDADR NONH for all modes of transport

WGK德国 3

RTECS QI9295900

商品规格

属性名称	属性值
储存温度 Storage temp.	2-8°C冷藏
全球实时库存 Availability √	美国St. Louis ≥ 300 \| 欧洲Eur. ≥ 90 \| 東京Tokyo ≥ 36 \| 香港与北京 ≥ 99

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盐酸阿霉素 [盐酸多柔比星]，Doxorubicin hydrochloride [DOX]；suitable for fluorescence, 98.0-102.0% (HPLC)

产品描述

General description

Application

包装

Biochem/physiol Actions

包装

Other Notes

法律信息

性质

安全信息

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