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盐酸阿霉素 [盐酸多柔比星],Doxorubicin hydrochloride [DOX];≥98% (HPLC), Calbiochem®

别名:阿霉素盐酸盐;多柔比星盐酸盐;羟基柔红霉素盐酸盐;14-羟基柔红霉素;14-羟基正定霉素;羟基正定霉素;亚得利亚霉素;亚德利亚霉素;DOX;Hydroxydaunorubicin hydrochloride

CAS号 25316-40-9 经验分子式(希尔表示法) C27H29NO11 · xHCl 分子量 543.52 (free base basis) MDL number MFCD00077757
货号(SKU): 324380
CAS号: 25316-40-9
MDL号: MFCD00077757
增值税发票 √ 免费货运 [顺丰 联邦] √
¥2,744.08

产品描述

General description

An anti-tumor antibiotic and a highly effective myotoxin that inhibits topoisomerase II (IC50 = 100 nM). Binds to nucleic acids, presumably by specific intercalation into the DNA double helix, inhibiting nucleic acid synthesis. Cytotoxicity seems to be due to its ability to intercalate with DNA, interact with plasma membranes, and take part in oxidation-reduction reactions. Induces apoptosis in rhabdomyosarcoma cell lines.

Antitumor antibiotic and a highly effective myotoxin that inhibits topoisomerase II (IC50 = 100 nM). Binds to nucleic acids, presumably by specific intercalation into the DNA double helix, thereby inhibiting nucleic acid synthesis. Induces apoptosis in rhabdomyosarcoma cell lines. Also available as a 10 mM solution in H2O (Cat. No. 504042).

Doxorubicin HCl, CAS 25316-40-9, is an antitumor antibiotic that inhibits topoisomerase II (IC₅₀ = 100 nM).

包装

10 mg in Plastic ampoule

Biochem/physiol Actions

Primary Target
topoisomerase 2

Product does not compete with ATP.

Warning

Toxicity: Carcinogenic / Teratogenic (D)

Reconstitution

Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C. Under acidic conditions doxorubicin is converted to a water-insoluble adriamycinone and a water soluble reducing sugar, daunosamine.

Other Notes

A′Hern, R.P., and Gore, M.E. 1995. J. Clin. Oncol. 13, 726.
Nooter, K., et al. 1995. Br. J. Cancer 71, 556.
Noviello, E., et al. 1994. Mutat. Res.311, 21.
Anderson, R.D., et al. 1993. Mutat. Res.294, 215.
Hershko, C., et al. 1993. J. Lab. Clin. Med.122, 245.
Jongmans, W., et al. 1993. Mutat. Res.294, 207.
O′Shaughnessy, J.A., and Cowan, K.H. 1993. J. Am. Med. Assoc.270, 2089.
Theyer, G., et al. 1993. J. Urol.150, 1544.
Tritton, T.R., and Yee, G. 1982. Science217, 248.

性质

Quality Level100
assay≥98% (HPLC)
formpowder
potency100 nM IC50
mfr. no.Calbiochem®
storage conditionOK to freeze
desiccated
protect from light
storage conditions+15C to +30C
colororange to red
solubilitywater: 10 mg/mL
shipped inambient
InChI1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10?,13?,15-,17?,22?,27-;/m0./s1
InChI keyMWWSFMDVAYGXBV-FGBJBKNOSA-N


安全信息

符号
信号词 Danger
危害声明 H302-H315-H319-H350
危害码 (欧洲) T,Xi
风险声明 (欧洲) 45-22-36/38
安全声明 (欧洲) 53-45
RIDADR NONH for all modes of transport
WGK德国 3
RTECS QI9295900
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 300 | 欧洲Eur. ≥ 90 | 東京Tokyo ≥ 36 | 香港与北京 ≥ 99
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