盐酸萘替芬，Naftifine hydrochloride；≥99%

图片 盐酸萘替芬，Naftifine hydrochloride；≥99%
别名：萘替芬盐酸盐；盐酸纳氟替芬；纳氟替芬盐酸盐；Empirical Formula (Hill Notation): C21H21N · HCl CAS号: 65473-14-5 分子量: 323.86 MDL编号: MFCD00059047 PubChem化学物质编号: 329818590
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: N1790
CAS号: 65473-14-5
MDL号: MFCD00059047
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¥2,534.03

说明

纳氟替芬是一种合成的广谱抗真菌剂和烯丙胺衍生物。局部用于治疗浅表性皮肤真菌病，如足癣、股癣和体癣。
纳氟替芬是一种具有抗真菌和抗真菌活性的烯丙胺化合物。纳夫蒂芬抑制真菌角鲨烯环氧化物酶并阻止麦角甾醇生物合成。纳氟替芬对革兰氏阳性和革兰氏阴性细菌也有抗菌活性。它已显示出抗炎特性，如超氧化物生成减少和多形核白细胞趋化性/内皮粘附减少。纳氟替芬似乎通过抑制角鲨烯2,3-环氧酶来干扰甾醇生物合成。这种抑制作用导致细胞中麦角甾醇的减少和角鲨烯的积累。
具有抗真菌和抗真菌活性的烯丙胺化合物。纳夫蒂芬抑制真菌角鲨烯环氧化物酶并阻止麦角甾醇生物合成。纳氟替芬还对革兰氏阳性和革兰氏阴性细菌具有抗菌活性，并具有抗炎特性。

应用

Naftifine is a synthetic, broad spectrum, antifungal agent and allylamine derivative. It is used topically to treat superficial dermatomycoses such as tinea pedis, tinea cruris, and tinea corporis.
 

生化/生理作用

Naftifine is an allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria. It has demonstrated anti-inflammatory properties such as a reduction in superoxide production and a reduction in polymorphonuclear leukocyte chemotaxis/endothelial adhesion. Naftifine appears to interfere with sterol biosynthesis by inhibiting the squalene 2,3-epoxidase. This inhibition results in decreased amounts of ergosterol and an accumulation of squalene in the cells.
Allylamine compound that has antifungal and antimycotic activities. Naftifine inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also has antibiotic activity against Gram-positive and Gram-negative bacteria and has demonstrated anti-inflammatory properties.
 

其他说明

Keep container tightly closed in a dry and well-ventilated place.Light sensitive.
 
 

属性

测定

≥99%

质量水平

200

形式

powder

溶解性

ethanol: soluble 50 mg/mL

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria
fungi
yeast

作用机制

cell wall synthesis | interferes
enzyme | inhibits

储存温度

2-8°C

SMILES string

Cl.CN(C\C=C\c1ccccc1)Cc2cccc3ccccc23

InChI

1S/C21H21N.ClH/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20;/h2-15H,16-17H2,1H3;1H/b11-8+;

InChI key

OLUNPKFOFGZHRT-YGCVIUNWSA-N

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

nwg

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 30 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 30
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