盐酸纳洛酮二水合物，Naloxone hydrochloride dihydrate；≥98% (TLC and titration), powder

别名：纳洛酮盐酸盐二水合物盐酸盐二水合物；Empirical Formula (Hill Notation): C19H21NO4 · HCl · 2H2O CAS号: 51481-60-8 分子量: 399.87 Beilstein: 6260807 MDL编号: MFCD00150901 PubChem化学物质编号: 24278050 NACRES: NA.77

制造商品牌: 西格玛 Sigma-Aldrich

货号（SKU）: N7758

CAS号: 51481-60-8

MDL号: MFCD00150901

增值税发票 √ 免费送货 √ 订货电话：010-68689484

目录价.SKU-Variant

250mg
1g [+¥2,745.00]

¥1,915.00

数量:

说明

应用

Naloxone hydrochloride dihydrate has been used in:

isotonic saline and injected subcutaneously into experimental rats to study its involvement with withdrawal syndrome in morphine-dependent rats
as opioid receptor antagonist to examine the role of the endogenous opioid system in infantile amnesia for contextual fear
as a reference neutral antagonist to define the maximum effect (Emax) of the system

生化/生理作用

Competitive antagonist for μ, κ, δ, and σ opioid receptors; blocks the action of σ-agonists at opioid sites. Naloxone′s antagonistic effect last for about 45 min and thus, requires repeated dosage. It results in critical side effects such as pulmonary edema.

特点和优势

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

注意

光敏。

属性

质量水平

200

测定

≥98% (TLC and titration)

形式

powder

旋光性

[α]25/D −178.6°, c = 2.5 in H₂O(lit.)

颜色

white to off-white

溶解性

ethanol: 3.3 mg/mL
H₂O: 50 mg/mL

储存温度

2-8°C

SMILES string

O.O.Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC=C

InChI

1S/C19H21NO4.ClH.2H2O/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;;;/h2-4,14,17,21,23H,1,5-10H2;1H;2*1H2/t14-,17+,18+,19-;;;/m1.../s1

InChI key

TXMZWEASFRBVKY-IOQDSZRYSA-N

Gene Information

human ... OPRD1(4985) , OPRK1(4986) , OPRM1(4988) , OPRS1(10280)

安全信息

象形图

GHS07

警示用语：

Warning

危险声明

H315 - H319 - H335

预防措施声明

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

商品规格

属性名称	属性值
储存温度 Storage temp.	2-8°C冷藏
全球实时库存 Availability √	美国St. Louis ≥ 55 \| 欧洲Eur. ≥ 16 \| 東京Tokyo ≥ 8 \| 香港与北京 ≥ 10