sevenspikes.themes.common.filters
sevenspikes.themes.common.closemenu

盐酸强力霉素 [盐酸多西环素],Doxycycline hyclate;≥98% (HPLC), Calbiochem®

别名:强力霉素盐酸盐;多西环素盐酸盐;多西环素单盐酸半乙醇半水合物;Doxycycline hydrochloride hemiethanolate hemihydrate;脱氧土霉素盐酸盐;6-甲基-4-(二甲氨基)-3,5,10,12,12a-五羟基-1,11-二氧代-1,4,4a,5,5a,6,11,12a-八氢-2-并四苯甲酰胺盐酸盐

CAS号 24390-14-5 经验分子式(希尔表示法) C22H24N2O8 · 0.5H2O · 0.5C2H6O · xHCl 分子量 476.48 (free base basis) MDL number MFCD07357237 NACRES NA.77
货号(SKU): 324385
CAS号: 24390-14-5
MDL号: MFCD07357237
增值税发票 √ 免费送货 √ 订货电话:010-68689484
HK$785.84

产品描述

General description

A commonly used broad-spectrum antibiotic. A potent inhibitor of MMP-8 (neutrophil collagenase; IC50 = 30 µM) relative to MMP-1 (collagenase-1; IC50 = 300 µM). Also inhibits collagen synthesis by bovine articular chondrocytes cultured in alginate (IC50 = 25 µM). Inhibits nitric oxide synthesis by LPS-activated macrophages without affecting IL-10 release.

A commonly-used broad-spectrum antibiotic. A potent inhibitor of MMP-8 (neutrophil collagenase; IC50 = 30 µM) relative to MMP-1 (interstitial collagenase; IC50 = 300 µM). Also inhibits collagen synthesis by bovine articular chondrocytes cultured in alginate (IC50 = 25 µM). Inhibits nitric oxide synthesis by LPS-activated macrophages without affecting IL-10 release.

包装

1 g in Glass bottle

Biochem/physiol Actions

Cell permeable: no

Primary Target
MMP-8

Product does not compete with ATP.

Reversible: no

Target IC50: 30 µM against MMP-8 (neutrophil collagenase); 25 µM inhibiting collagen synthesis by bovine articular chondrocytes cultured in alginate

Warning

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Reconstitution

Follwing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 5 days at 4°C.

Other Notes

D’Agostino, P., et al. 1998. J. Infect. Dis. 177, 489.
Beekman, B., et al. 1997. Biochem. Biophys. Res. Commun. 237, 107.
Hanemaaijer, R., et al. 1997. J. Biol. Chem. 272, 31504.
Lauhio, A., et al. 1994. Clin. Exp. Immunol. Antimicrobiol. Agents Chemother. 36, 227.
Sorsa, T., et al. 1994. Ann. N.Y. Acad. Sci.732, 112.
Suomalainen, K., et al. 1992. Antimicrobiol. Agents Chemother.36, 227.

性质

Quality Level100
assay≥98% (HPLC)
formcrystalline solid
mfr. no.Calbiochem®
storage conditionOK to freeze
desiccated
storage conditions+2C to +8C
coloryellow to yellow-green
solubilitywater: 50 mg/mL
shipped inambient
InChI1S/2C22H24N2O8.C2H6O.2ClH.H2O/c2*1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;1-2-3;;;/h2*4-7,10,14-15,17,25-27,31-32H,23H2,1-3H3;3H,2H2,1H3;2*1H;1H2/b2*21-13+;;;;/t2*7-,10+,14+,15-,17-,22-;;;;/m00..../s1
InChI keyQDDHZFKCHWYXJF-PCLMCNLLSA-N


安全信息

符号
GHS07  GHS07
信号词 Warning
靶器官 Respiratory system
个人防护装备 dust mask type N95 (US)EyeshieldsGloves
危害码 (欧洲) Xn
风险声明 (欧洲) 22-36/37/38
安全声明 (欧洲) 26
RIDADR NONH for all modes of transport
WGK德国 WGK 3
RTECS QI8925000
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 190 | 欧洲Eur. ≥ 66 | 東京Tokyo ≥ 82 | 香港与北京 ≥ 55