General description
A commonly used broad-spectrum antibiotic. A potent inhibitor of MMP-8 (neutrophil collagenase; IC50 = 30 µM) relative to MMP-1 (collagenase-1; IC50 = 300 µM). Also inhibits collagen synthesis by bovine articular chondrocytes cultured in alginate (IC50 = 25 µM). Inhibits nitric oxide synthesis by LPS-activated macrophages without affecting IL-10 release.
A commonly-used broad-spectrum antibiotic. A potent inhibitor of MMP-8 (neutrophil collagenase; IC50 = 30 µM) relative to MMP-1 (interstitial collagenase; IC50 = 300 µM). Also inhibits collagen synthesis by bovine articular chondrocytes cultured in alginate (IC50 = 25 µM). Inhibits nitric oxide synthesis by LPS-activated macrophages without affecting IL-10 release.
包装
1 g in Glass bottle
Biochem/physiol Actions
Cell permeable: no
Primary Target
MMP-8
Product does not compete with ATP.
Reversible: no
Target IC50: 30 µM against MMP-8 (neutrophil collagenase); 25 µM inhibiting collagen synthesis by bovine articular chondrocytes cultured in alginate
Warning
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
Reconstitution
Follwing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 5 days at 4°C.
Other Notes
D’Agostino, P., et al. 1998. J. Infect. Dis. 177, 489.
Beekman, B., et al. 1997. Biochem. Biophys. Res. Commun. 237, 107.
Hanemaaijer, R., et al. 1997. J. Biol. Chem. 272, 31504.
Lauhio, A., et al. 1994. Clin. Exp. Immunol. Antimicrobiol. Agents Chemother. 36, 227.
Sorsa, T., et al. 1994. Ann. N.Y. Acad. Sci.732, 112.
Suomalainen, K., et al. 1992. Antimicrobiol. Agents Chemother.36, 227.