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盐酸吉西他滨 [dFdC, dFdCyd],Gemcitabine hydrochloride;≥98% (HPLC)

别名:吉西他滨盐酸盐;2';-脱氧-2',2'-二氟胞苷; 盐酸吉西他宾;吉西他宾盐酸盐;2′-Deoxy-2′,2′-difluorocytidine;dFdC;Gemzar (Lilly);LY-188011;dFdC;dFdCyd

CAS号 122111-03-9 经验分子式(希尔表示法) C9H11F2N3O4 · HCl 分子量 299.66 MDL number MFCD01735988 PubChem Substance ID 329799951 NACRES NA.77
货号(SKU): G6423
CAS号: 122111-03-9
MDL号: MFCD01735988
增值税发票 √ 免费货运 [顺丰 联邦] √
¥732.00

产品描述

一种DNA合成抑制剂, 在BxPC-3, Mia Paca-2, PANC-1, PL-45和AsPC-1细胞中的IC50分别为37.6, 42.9, 92.7, 89.3 和131.4 nM

包装

10, 50 mg in glass bottle

Biochem/physiol Actions

吉西他滨是诊所和研究实验室中广泛使用的抗肿瘤药物。它是一种抗肿瘤药和抗代谢药。

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

法律信息

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

性质

Quality Level100
assay≥98% (HPLC)
formpowder
storage conditiondesiccated
protect from light
solubilityH2O: ≥10 mg/mL
originatorEli Lilly
storage temp.room temp
SMILES stringCl.NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)C2(F)F
InChI1S/C9H11F2N3O4.ClH/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17;/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17);1H/t4-,6-,7-;/m1./s1
InChI keyOKKDEIYWILRZIA-OSZBKLCCSA-N
Gene Informationhuman ... POLA1(5422), POLA2(23649), POLD1(5424), POLD2(5425), POLD3(10714), POLD4(57804), POLE(5426), POLE2(5427), POLE3(54107), PRIM1(5557), PRIM2(5558), RRM1(6240), RRM2(6241), RRM2B(50484)


安全信息

符号
GHS08  GHS08
信号词 Danger
危害声明 H360
警示性声明 P201 - P308 + P313
危害码 (欧洲) Xn
风险声明 (欧洲) 63-62
安全声明 (欧洲) 53-36/37
RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 88 | 欧洲Eur. ≥ 126 | 東京Tokyo ≥ 46 | 香港与北京 ≥ 62
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