一种DNA合成抑制剂, 在BxPC-3, Mia Paca-2, PANC-1, PL-45和AsPC-1细胞中的IC50分别为37.6, 42.9, 92.7, 89.3 和131.4 nM
包装
10, 50 mg in glass bottle
Biochem/physiol Actions
吉西他滨是诊所和研究实验室中广泛使用的抗肿瘤药物。它是一种抗肿瘤药和抗代谢药。Features and Benefits
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
法律信息
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
性质
Quality Level | 100 |
assay | ≥98% (HPLC) |
form | powder |
storage condition | desiccated |
| protect from light |
solubility | H2O: ≥10 mg/mL |
originator | Eli Lilly |
storage temp. | room temp |
SMILES string | Cl.NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)C2(F)FInChI | 1S/C9H11F2N3O4.ClH/c10-9(11)6(16)4(3-15)18-7(9)14-2-1-5(12)13-8(14)17;/h1-2,4,6-7,15-16H,3H2,(H2,12,13,17);1H/t4-,6-,7-;/m1./s1InChI key | OKKDEIYWILRZIA-OSZBKLCCSA-NGene Information | human ... POLA1(5422), POLA2(23649), POLD1(5424), POLD2(5425), POLD3(10714), POLD4(57804), POLE(5426), POLE2(5427), POLE3(54107), PRIM1(5557), PRIM2(5558), RRM1(6240), RRM2(6241), RRM2B(50484) | | | |
安全信息
RIDADR NONH for all modes of transport