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盐酸二甲双胍 [甲福明],Metformin hydrochloride;Calbiochem, ≥97% (titration)

别名:二甲双胍盐酸盐,盐酸甲福明,1,1-Dimethylbiguanide hydrochloride,Metformin

CAS号 1115-70-4 经验分子式(希尔表示法) C4H11N5 · xHCl 分子量 129.16 (free base basis) MDL number MFCD00012582 NACRES NA.77
货号(SKU): 317240
CAS号: 1115-70-4
MDL号: MFCD00012582
增值税发票 √ 免费货运 [顺丰 联邦] √
HK$1,694.16

产品描述

An antihyperglycemic agent that lowers blood glucose levels without stimulating insulin secretion, promoting weight gain or causing hypoglycemia.

一种降血糖药,可降低血糖水平而不刺激胰岛素分泌,促进体重增加或引起低血糖症。

General description

An anti-hyperglycemic agent that acts by lowering the hepatic output of glucose. Does not stimulate insulin secretion, promote weight gain, or cause hypoglycemia. Reported to stimulate AMP-activated protein kinase (AMPK), leading to the reduction in acetyl-CoA carboxylase (ACC) activity and induction of fatty acid oxidation.

An antihyperglycemic agent that lowers blood glucose levels without stimulating insulin secretion, promoting weight gain or causing hypoglycemia. Reported to stimulate AMP-activated protein kinase (AMPK) leading to the reduction in acetyl-CoA carboxylase (ACC) activity and induction of fatty acid oxidation.

一种抗降血糖药,可通过降低肝脏的葡萄糖输出量发挥作用。 不刺激胰岛素分泌,促进体重增加或引起低血糖症。 据报道可刺激AMP激活的蛋白激酶(AMPK),从而导致乙酰辅酶A羧化酶(ACC)活性降低并诱导脂肪酸氧化。一种降血糖药,可降低血糖水平而不刺激胰岛素分泌,促进体重增加或引起低血糖症。 据报道刺激AMP激活的蛋白激酶(AMPK)导致乙酰辅酶A羧化酶(ACC)活性降低和脂肪酸氧化诱导。

包装

5 g in Glass bottle

Biochem/physiol Actions

Cell permeable: no

Primary Target
AMP-activated protein kinase (AMPK)

Product does not compete with ATP.

Reversible: no

包装

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Cleasby, M.E., et al. 2004. Diabetes53, 3258.
Klein, J., et al. 2004. J. Endocrinol.183, 299.
Zhou, G., et al. 2001. J. Clin. Invest.108, 1167.
Lin, H.Z., et al. 2000. Nat. Med.6, 998.

性质

Quality Level100
assay≥97% (titration)
formsolid
mfr. no.Calbiochem®
storage conditionOK to freeze
desiccated
storage conditions+15C to +30C
colorwhite
solubilitywater: 50 mg/mL
shipped inambient
InChI1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H
InChI keyOETHQSJEHLVLGH-UHFFFAOYSA-N


安全信息

符号
GHS07  GHS07
信号词 Warning
危害声明 H302
个人防护装备 dust mask type N95 (US)EyeshieldsGloves
危害码 (欧洲) Xn
风险声明 (欧洲) 22-36/38
安全声明 (欧洲) 26-36
RIDADR NONH for all modes of transport
WGK德国 WGK 3
RTECS DU1800000
商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 190 | 欧洲Eur. ≥ 66 | 東京Tokyo ≥ 82 | 香港与北京 ≥ 55