盐酸二甲双胍 [甲福明]，Metformin hydrochloride；Calbiochem, ≥97% (titration)

General description

An anti-hyperglycemic agent that acts by lowering the hepatic output of glucose. Does not stimulate insulin secretion, promote weight gain, or cause hypoglycemia. Reported to stimulate AMP-activated protein kinase (AMPK), leading to the reduction in acetyl-CoA carboxylase (ACC) activity and induction of fatty acid oxidation.

An antihyperglycemic agent that lowers blood glucose levels without stimulating insulin secretion, promoting weight gain or causing hypoglycemia. Reported to stimulate AMP-activated protein kinase (AMPK) leading to the reduction in acetyl-CoA carboxylase (ACC) activity and induction of fatty acid oxidation.

一种抗降血糖药，可通过降低肝脏的葡萄糖输出量发挥作用。 不刺激胰岛素分泌，促进体重增加或引起低血糖症。 据报道可刺激AMP激活的蛋白激酶（AMPK），从而导致乙酰辅酶A羧化酶（ACC）活性降低并诱导脂肪酸氧化。一种降血糖药，可降低血糖水平而不刺激胰岛素分泌，促进体重增加或引起低血糖症。 据报道刺激AMP激活的蛋白激酶（AMPK）导致乙酰辅酶A羧化酶（ACC）活性降低和脂肪酸氧化诱导。

包装

5 g in Glass bottle

Biochem/physiol Actions

Cell permeable: no

Primary Target
AMP-activated protein kinase (AMPK)

Product does not compete with ATP.

Reversible: no

包装

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Cleasby, M.E., et al. 2004. Diabetes53, 3258.
Klein, J., et al. 2004. J. Endocrinol.183, 299.
Zhou, G., et al. 2001. J. Clin. Invest.108, 1167.
Lin, H.Z., et al. 2000. Nat. Med.6, 998.

性质

安全信息

符号

  GHS07

信号词 Warning

危害声明 H302

警示性声明 P264 - P270 - P301 + P312 - P501

个人防护装备 dust mask type N95 (US), Eyeshields, Gloves

危害码 (欧洲) Xn

风险声明 (欧洲) 22-36/38

安全声明 (欧洲) 26-36

RIDADR NONH for all modes of transport

WGK德国 WGK 3

RTECS DU1800000