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益康唑硝酸盐 [硝酸益康唑],Econazole nitrate salt;powder or crystals

别名:伊康唑;1-(2-[(4-氯苯基)甲氧基]-2-[2,4-二氯苯基]乙基)-1H-咪唑;1-(2-[(4-Chlorophenyl)methoxy]-2-[2,4-dichlorophenyl]ethyl)-1H-imidazole

Empirical Formula (Hill Notation): C18H15Cl3N2O · HNO3 CAS号: 24169-02-6 分子量: 444.70 EC 号: 246-053-5 MDL编号: MFCD00058160 PubChem化学物质编号: 24894567 NACRES: NA.85
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): E4632
CAS号: 24169-02-6
MDL号: MFCD00058160
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说明

化学结构:咪唑
伊康唑是一种广谱抗真菌药,类似于酮康唑。它对革兰氏阳性菌有一定作用。局部用于皮肤真菌病以及口服和胃肠外用药。它用于研究血小板5-羟色胺摄取、前列腺素类生物合成、EDHF介导的舒张和胸腺淋巴细胞中Ca2+转运途径等过程。
伊康唑与14-α去甲基化酶相互作用,14-α脱甲基化酶是将羊毛甾醇转化为麦角甾醇所必需的细胞色素P-450酶。麦角甾醇的抑制导致细胞渗透性增加,导致细胞内容物泄漏。Econazole还可能抑制内源性呼吸,与膜磷脂相互作用,抑制酵母向菌丝体的转化,抑制嘌呤摄取,并损害甘油三酯和磷脂的生物合成。

一般描述

Chemical structure: imidazole
 

应用

Econazole is a broad spectrum antimycotic similar to ketoconazole. It has some action against Gram positive bacteria. It is used topically in dermatomycoses as well as orally and parenterally. It is used for studies on processes such as platelet serotonin uptake, prostanoid biosynthesis, EDHF-mediated relaxation, and Ca2+ transport pathways in thymic lymphocytes.
 

生化/生理作用

Econazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. Inhibition of ergosterol results in increased cellular permeability causing leakage of cellular contents. Econazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and phospholipid biosynthesis.
 
 

属性

形式

powder or crystals

质量水平

200

颜色

white to off-white

抗生素抗菌谱

Gram-positive bacteria
fungi

作用机制

cell membrane | interferes
cell wall synthesis | interferes
enzyme | inhibits

SMILES string

O[N+]([O-])=O.Clc1ccc(COC(Cn2ccnc2)c3ccc(Cl)cc3Cl)cc1

InChI

1S/C18H15Cl3N2O.HNO3/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21;2-1(3)4/h1-9,12,18H,10-11H2;(H,2,3,4)

InChI key

DDXORDQKGIZAME-UHFFFAOYSA-N

 

安全信息

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

储存分类代码

11 - Combustible Solids

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 55 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 8 | 香港与北京 ≥ 10
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