白藜芦醇是一种天然多酚,具有抗氧化,抗炎,保护心脏和抗癌的特性, 它的靶点广泛,如:mTOR,JAK,β-amyloid,Adenylyl cyclase,IKKβ,DNA polymerase等。
Application
Resveratrol has been used:
• in entrapment experiment
• to study its neuroprotective effect on retinal neuronal cell death mediated by diabetes-induced activation of Ca2+/calmodulin-dependent protein kinase II
• as a standard in the assessment of stilbene content in grapevine leaf by in vivo fluorometry
COX-1 选择性抑制剂。
Biochem/physiol Actions
Resveratrol is a phenolic phytoalexin found in grape skin and other plants. It has intracellular antioxidant activity and activates sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylase involved in mitochondrial biogenesis and the enhancement of peroxisome proliferator-g-activated receptor coactivator-1a (PGC-1a) and FOXO (forkhead box) activity. The anti-diabetic, neuroprotective and anti-adipogenic actions of resveratrol may be mediated via SIRT1 activation. Resveratrol has antiviral action against Herpes simplex virus-1 (HSV1) and HSV2. It also exhibits antitumor and phytoestrogenic biological activities. Resveratrol is known to prolong life in many species by mediating several physiological events.
Preparation Note
可溶于乙醇、DMSO和丙酮。 仅有极少量的可溶于水(3 mg/100 mL)。
性质
biological source | plant root (bushy knotweed) |
assay | ≥99% (HPLC) |
form | powder |
solubility | acetone: 50 mg/mL, clear, faintly yellow |
storage temp. | −20°C |
SMILES string | Oc1ccc(cc1)\C=C\c2cc(O)cc(O)c2InChI | 1S/C14H12O3/c15-12-5-3-10(4-6-12)1-2-11-7-13(16)9-14(17)8-11/h1-9,15-17H/b2-1+InChI key | LUKBXSAWLPMMSZ-OWOJBTEDSA-NGene Information | human ... AR(367), CYP1A2(1544), ESR1(2099), SIRT1(23411) mouse ... Nos2(18126) rat ... Esr1(24890) | | | |
安全信息
RIDADR NONH for all modes of transport