疏水相互作用层析树脂,Capto Butyl ImpRes hydrophobic interaction chromatography resin

Capto Butyl ImpRes是一种HIC树脂,用于下游纯化过程中的中间和抛光步骤。17371902;17371901;17371904;17371903
货号(SKU): 17371903
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Capto Butyl ImpRes is a HIC resin for the intermediate and polishing steps in a downstream purification process.

基于 Capto ImpRes 基础基质的高分辨率纯化,具有传统的 HIC 配体和较小的平均粒径。
与 Capto Butyl 相比,更高的吞吐量可能会提高生产率和工艺经济性。
Resin 满足工业对供应安全性、强大性能和监管支持的需求。
Capto Butyl ImpRes 是一种生物过程层析树脂,专为生物制药蛋白质的大规模纯化而开发。基于成熟的 Capto 基础基质和传统的丁基配体,这种高分辨率树脂为提高生产率和简单的工艺开发提供了许多机会。

通过将 Capto 树脂的高流动特性与较小的粒径相结合,Capto Butyl ImpRes 可提供出色的压力/流动特性和分辨率。在更高流速和更高床层高度下运行的能力增加了工艺设计的灵活性并促进了生产率的提高。

  • High-resolution purification based on Capto ImpRes base matrix with a traditional HIC ligand and smaller average particle size.
  • Flexible process design due to a large operational window of flow velocities and bed heights.
  • Higher throughput compared with Capto Butyl might enable improved productivity and process economy.
  • Excellent chemical stability.
  • Resin fulfills industrial demands for security of supply, robust performance, and regulatory support.

Get improved flexibility and productivity

Capto Butyl ImpRes is a bioprocess chromatography resin developed for large-scale purification of biopharmaceutical proteins. Based on the well-established Capto base matrix with traditional butyl ligands, this high-resolution resin provides many opportunities for improved productivity and straightforward process development.

Smaller particle size

By combining the high-flow characteristics of Capto resin with a smaller particle size, Capto Butyl ImpRes deliver both excellent pressure/flow properties and resolution. The ability to run at higher flow velocities and higher bed heights increases flexibility in process design and facilitates increased productivity.

Prepacked columns and other formats

Capto Butyl ImpRes resin is available in the following formats: 

Process development scale: prepacked

HiScreen Capto Butyl ImpRes columns, optimized for method and process development.

Lab scale: prepacked for manual purification

HiTrap Capto Butyl ImpRes columns, for easy use with a syringe, peristaltic pump, or chromatography system.

Lab scale: prepacked for automated purification and analysis

HiTrap Capto Butyl ImpRes columns, for easy use with a syringe, peristaltic pump, or chromatography system.

Process characterization: resin kits

Process Characterization Kit Capto Butyl ImpRes, designed for studying the potential impact that resin ligand density might have on the process outcome.


ParameterCapto Butyl ImpRes, 1 L
Chromatography techniqueHydrophobic Interaction Chromatography 
BioProcess resinYes 
Particle size, d50V1~40 µm 
MatrixHigh Flow Agarose 
Binding Capacity/ml Chromatography Medium237 mg BSA /mL  
Pressure/Flow SpecificationUp to 220 cm/h in a 1 m diameter column with a bed height of 20 cm at 20°C using process buffers with the same viscosity as water at 300 kPa. 
Storage20% ethanol at 4°C to 30°C 
Estimated shelf life from manufacture date5 years 
Chemical stability3Stable in commonly used aqueous buffers, 1 M sodium hydroxide 
Pack size1 L 
  • 1Median particle size of the cumulative volume distribution.
  • 2Dynamic binding capacity at 10% breakthrough measured at a residence time of 4 min (150 cm/h) in Tricorn 5/100 column with 10 cm bed height. Buffer conditions: 0.1 M sodium phosphate buffer, 1.2 M ammonium sulfate, pH 7.
  • 3No significant change in function after one month storage in 1 M NaOH at ambient temperature.
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16