甲苯磺酸索拉非尼，Sorafenib tosylate；≥98% (HPLC)

图片 甲苯磺酸索拉非尼，Sorafenib tosylate；≥98% (HPLC)
别名：甲苯磺酸索拉菲尼；索拉非尼甲苯磺酸盐；4-[4-[[[4-氯-3-(三氟甲基)苯基]氨基]羰基]氨基]苯氧基]-N-甲基-2-吡啶甲酰胺,4-甲基苯磺酸盐，BAY 43-9006甲苯磺酸盐，BAY43-9006甲苯磺酸盐，N-[4-氯-3-（三氟甲基）苯基]-N'-[4-[2-（N-甲基氨基甲酰基）-4-吡啶氧基]苯基]脲,4-甲基苯磺酸盐；4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide, 4-methylbenzenesulfonate, BAY 43-9006 tosylate salt, BAY43-9006 tosylate salt, N-[4-Chloro-3-(trifluoromethyl)phenyl]-N′-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea, 4-methylbenzenesulfonate

Empirical Formula (Hill Notation): C21H16ClF3N4O3·C7H8SO3 CAS号: 475207-59-1 分子量: 637.03 MDL编号: MFCD08235032
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: SML2633
CAS号: 475207-59-1
MDL号: MFCD08235032
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说明

口服活性激酶抑制剂索拉非尼（BAY 43-9006）的甲苯磺酸盐，通过靶向b-Raf，c-Raf（Raf-1）以及几种参与的受体酪氨酸激酶在体外和体内发挥广谱抗癌功效新血管形成和肿瘤进展，包括血管内皮生长因子受体2/3（VEGFR-2/Flk-1/KDR，VEGFR-3），血小板衍生生长因子受体β（PDGFR-β），Flt-3，c-KIT，FGFR-1（Flt-2）和RET。

生化/生理作用

Tosylate salt of the orally active kinase inhibitor Sorafenib (BAY 43-9006) that exerts broad-spectrum anticancer efficacy in vitro and in vivo via targeting b-Raf, c-Raf (Raf-1), as well as several receptor tyrosine kinases involved in neovascularization and tumor progression, including vascular endothelial growth factor receptors 2/3 (VEGFR-2/Flk-1/KDR, VEGFR-3), platelet-derived growth factor receptor-beta (PDGFR-β), Flt-3, c-KIT, FGFR-1 (Flt-2) and RET.
 
 

属性

测定

≥98% (HPLC)

形式

powder

储存条件

desiccated

颜色

white to very dark brown

溶解性

DMSO: 2 mg/mL, clear

储存温度

2-8°C

InChI

1S/C21H16ClF3N4O3.C7H8O3S/c1-26-19(30)18-11-15(8-9-27-18)32-14-5-2-12(3-6-14)28-20(31)29-13-4-7-17(22)16(10-13)21(23,24)25;1-6-2-4-7(5-3-6)11(8,9)10/h2-11H,1H3,(H,26,30)(H2,28,29,31);2-5H,1H3,(H,8,9,10)

InChI key

IVDHYUQIDRJSTI-UHFFFAOYSA-N

 

安全信息

象形图

Health hazardEnvironment
GHS08,GHS09

警示用语：

Danger

危险分类

Aquatic Acute 1 - Aquatic Chronic 1 - Lact. - Repr. 1B - STOT RE 1

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

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