甲磺酸苯扎托品，Benztropine mesylate；≥99.0%(HPLC)

图片 甲磺酸苯扎托品，Benztropine mesylate；≥99.0%(HPLC)
苯扎托品甲磺酸盐；苯托品甲磺酸盐；Cogentin；Empirical Formula (Hill Notation): C21H2NO · xCH4O3S CAS号: 132-17-2 分子量: 284.25 (free base basis) MDL编号: MFCD00074784
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: SML0847
CAS号: 132-17-2
MDL号: MFCD00074784
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¥643.00

说明

一般描述

Benztropine mesylate is an anti-histamine and dopamine re-uptake inhibitor.[1]
 

应用

Benztropine mesylate has been used to study its target identification and mode of action against ebolavirus infection.[2] It has also been used in pharmacological animal studies to evaluate its effect on SLC6A19 (solute carrier family 6 member 19; B0AT1).[3]
 

生化/生理作用

Benztropine mesylate is a centrally acting muscarinic acetylcholine receptor antagonist and dopamine transporter (DAT) inhibitor (IC50 = 118 nM). Benztropine mesylate has been used to treat the symptoms of Parkinson′s disease and is currently in clincial trials for chronic back pain.
Benztropine mesylate serves as an inhibitor of breast cancer stem cells (BCSCs) in vitro and in vivo. It can help in improving the efficacy of chemotherapy in vitro. It is considered as an anti-cancer stem cell (CSC) drug, which can modify tumorigenic properties.[1]
 

特点和优势

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) and Biogenic Amine Transporters pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
 
 

属性

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

储存条件

desiccated

颜色

white to beige

溶解性

H2O: 20 mg/mL, clear

储存温度

2-8°C

SMILES string

CS(O)(=O)=O.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(c3ccccc3)c4ccccc4

InChI

1S/C21H25NO.CH4O3S/c1-22-18-12-13-19(22)15-20(14-18)23-21(16-8-4-2-5-9-16)17-10-6-3-7-11-17;1-5(2,3)4/h2-11,18-21H,12-15H2,1H3;1H3,(H,2,3,4)/t18-,19+,20+;

InChI key

CPFJLLXFNPCTDW-BWSPSPBFSA-N

Gene Information

human ... CHRM1(1128)

 

安全信息

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H302 - H311 + H331

危险分类

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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