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甲氨蝶呤 [氨甲喋呤, MTX],Methotrexate;Pharmaceutical Secondary Standard; Certified Reference Material

别名:(+)-氨甲蝶呤;MTX;氟安定;氨甲叶酸;4-氨基-N10-甲基巯基-L-谷氨酸;(+)-Amethopterin, 4-Amino-10-methylfolic acid, 4-Amino-N10-methylpteroyl-L-glutamic acid, Antifolan, MTX, Methotrexate, Methylaminopterin

CAS号 59-05-2 经验分子式(希尔表示法) C20H22N8O5 分子量 454.44 Beilstein/REAXYS Number 70669 EINECS 编号 200-413-8 MDL number MFCD00064370 PubChem Substance ID 329823370 NACRES NA.24
货号(SKU): PHR1396
CAS号: 59-05-2
MDL号: MFCD00064370
增值税发票 √ 免费货运 [顺丰 联邦] √
¥1,124.68

产品描述

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Methotrexate is an antagonist of folic acid that inhibits dihydrofolate reductase (DHFR) enzyme, reversibly and results in impaired DNA synthesis and cellular replication.[1] Methotrexate has been used in treatment of rheumatoid arthritis[2] and also for maintenance therapy in childhood acute lymphocytic leukemia (ALL).[3]

Application

Methotrexate may be used as a pharmaceutical secondary reference standard for the determination of the analyte in plasma samples[4] and pharmaceutical formulations[5] by various techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

这些二级标准品可追溯至USP、EP(PhEur)和BP一级标准品。

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

要查看该材料的分析证书示例,请在下面的栏位中输入LRAB9958。这只是一个示例证书,可能不是您收到的批次。

性质

Quality Level300
gradecertified reference material
pharmaceutical secondary standard
formneat
application(s)HPLC: suitable
gas chromatography (GC): suitable
Featured IndustryPharmaceutical (small molecule)
formatneat
pharmacopeia traceabilitytraceable to PhEur M1000000
traceable to USP 1414003
SMILES stringCN(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O
InChI1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m0/s1
InChI keyFBOZXECLQNJBKD-ZDUSSCGKSA-N
Gene Informationhuman ... DHFR(1719)


安全信息

符号
信号词 Danger
危害码 (欧洲) T
风险声明 (欧洲) 46-61-25-36/38
安全声明 (欧洲) 53-26-36-45
RIDADR UN 1544PSN1 6.1 / PGIII
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 88 | 欧洲Eur. ≥ 126 | 東京Tokyo ≥ 46 | 香港与北京 ≥ 62
商品标签