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甲基莲心碱,Neferine;≥98% (HPLC)

别名:4''-O-甲基莲心碱;4-[[(1S)-1,2,3,4-四氢-6,7-二甲氧基-2-甲基-1-异喹啉基]甲基]-2-[[(1R)-1,2,3,4 -四氢-6-甲氧基-1-[(4-甲氧基苯基)甲基]-2-甲基-7-异喹啉基]氧基]-苯酚;Neferin, Methylliensinine, 4-[[(1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]-2-[[(1R)-1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-7-isoquinolinyl]oxy]-phenol, (-)-Neferine, 4′′-O-Methylliensinine

Empirical Formula (Hill Notation): C38H44N2O6 CAS号: 2292-16-2 分子量: 624.77 MDL编号: MFCD22416529 PubChem化学物质编号: 329825352 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML0349
CAS号: 2292-16-2
MDL号: MFCD22416529
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¥2,516.35

说明

甲基莲心碱已被用于研究其在自噬信号传导中的作用。

甲基莲心碱是一种从绿色种子 Nelumbo Nucifera Gaertn (Lotus) 中分离出来的双苄基异喹啉生物碱,具有多种药理活性,包括抗肿瘤、抗抑郁和抗心律失常作用。 最近的研究表明,neferine 有效抑制人骨肉瘤细胞的增殖,而对非肿瘤性人成骨细胞毒性低。 显然,在 U2OS 细胞中,甲基莲心碱通过激活 p38 MAPK 来稳定 p21,从而导致 G1 细胞周期停滞。 此外,甲基莲心碱通过上调 HO-1 抑制 Ang II 诱导的 HUVSMC 增殖。

应用

Neferine has been used to study its effect in autophagy signalling.
 

生化/生理作用

Neferine is a bis-benzylisoquinoline alkaloid isolated from the green seed embryos Nelumbo Nucifera Gaertn (Lotus) that displays multiple pharmacological activities including anti-tumor, antidepressant-like and antiarrhythmic actions. Recent studies shown that neferine potently inhibits proliferation of human osteosarcoma cells while is low-toxic on non-neoplastic human osteoblast cells. Apparently in U2OS cells, neferine stabilizes p21 through the activation of p38 MAPK, which leads to G1 cell cycle arrest. Also, neferine inhibits Ang II-induced HUVSMC proliferation by upregulation of HO-1.
 

特点和优势

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
 
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

旋光性

[α]/D -34 to -44° (c=0 3. CHCl3)

储存条件

desiccated
protect from light

颜色

white to beige

溶解性

DMSO: >15 mg/mL

储存温度

2-8°C

SMILES string

COc1ccc(C[C@H]2N(C)CCc3cc(OC)c(Oc4cc(C[C@@H]5N(C)CCc6cc(OC)c(OC)cc56)ccc4O)cc23)cc1

InChI

1S/C38H44N2O6/c1-39-15-14-27-21-36(44-5)38(23-30(27)31(39)17-24-7-10-28(42-3)11-8-24)46-34-19-25(9-12-33(34)41)18-32-29-22-37(45-6)35(43-4)20-26(29)13-16-40(32)2/h7-12,19-23,31-32,41H,13-18H2,1-6H3/t31-,32+/m1/s1

InChI key

MIBATSHDJRIUJK-ZWXJPIIXSA-N

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32