环格列酮，Ciglitizone；≥98% (HPLC)

图片 环格列酮，Ciglitizone；≥98% (HPLC)
别名：（±）-5- [4-（1-（甲基环己基甲氧基）苄基]噻唑烷-2,4-二酮；西格列酮；(±)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]thiazolidine-2,4-dione；Ciglitazone

Empirical Formula (Hill Notation): C18H23NO3S CAS号: 74772-77-3 分子量: 333.45 MDL编号: MFCD00865499 PubChem化学物质编号: 24892661 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: C3974
CAS号: 74772-77-3
MDL号: MFCD00865499
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说明

Ciglitizone 属于噻唑烷二酮类，是一种过氧化物酶体增殖物激活受体 γ (PPARγ) 激动剂。 它表现出抗糖尿病活性。 Ciglitizone 具有治疗肿瘤坏死因子α (TNFα) 相关凋亡诱导配体 (TRAIL) 难治性高级别尿路上皮癌的潜力。

应用

Ciglitizone has been used as a proliferator-activated receptor γ (PPARγ) agonist:
  • to study its effects on cell proliferation in human melanocytes
  • to study its effects on pigmentation and migration of human melanocytes
It also may be used to study its effects on cell cycle and apoptosis in monocytic cells.
 

生化/生理作用

Ciglitizone belongs to the class of thiazolidinediones and is a peroxisome proliferator-activated receptor γ (PPARγ) agonist. It exhibits anti-diabetic activity. Ciglitizone has the potential to treat tumor necrosis factor α (TNFα)-related apoptosis-inducing ligand (TRAIL)-refractory high-grade urothelial cancers.
 

特点和优势

This compound was developed by Takeda. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
 
 

属性

质量水平

100

测定

≥98% (HPLC)

创始人

Takeda

SMILES string

CC1(CCCCC1)COc2ccc(CC3SC(=O)NC3=O)cc2

InChI

1S/C18H23NO3S/c1-18(9-3-2-4-10-18)12-22-14-7-5-13(6-8-14)11-15-16(20)19-17(21)23-15/h5-8,15H,2-4,9-12H2,1H3,(H,19,20,21)

InChI key

YZFWTZACSRHJQD-UHFFFAOYSA-N

Gene Information

human ... PPARG(5468)
mouse ... Pparg(19016)

 

安全信息

储存分类代码

12 - Non Combustible Liquids

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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