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环孢霉素A [环孢素A, 环孢菌素A],Cyclosporin A;VETRANAL®, analytical standard

别名:环胞霉素A;环胞素A;环胞菌素A;环孢多肽A;环孢灵;赛斯平;山地明;环孢素;新山地明;抗生素S7481F1;Antibiotic S 7481F1;Cyclosporine

Empirical Formula (Hill Notation): C62H111N11O12 CAS号: 59865-13-3 分子量: 1202.61 Beilstein: 3647785 MDL编号: MFCD00274558 PubChem化学物质编号: 329754203 NACRES: NA.24
货号(SKU): 32425
CAS号: 59865-13-3
MDL号: MFCD00274558
签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √
¥3,392.00

说明

环孢菌素A(CsA)是一种真菌代谢产物,一种环状十一肽。它具有高度特异性的免疫抑制作用,骨髓毒性低,因此成为人体器官移植的一种有价值的药物。其免疫抑制活性基于其抑制T淋巴细胞活化的早期步骤(如淋巴因子基因转录)的能力。

一般描述

Cyclosporin A (CsA) is a fungal metabolite, a cyclic undecapeptide. It has highly specific immunosuppressive effects with low myelotoxicity, thereby making it a valuable drug in human organ transplantation. Its immunosuppressive activity is based upon its ability to inhibit early steps of T-lymphocyte activation such as lymphokine gene transcription.
Cyclosporin A has been used to:
  • Prevent rejection of kidney and liver transplants.
  • In graft versus host disease.
  • Treatment of autoimmune diseases.
  • Treatment of Schistosomiasis.

应用

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
 

生化/生理作用

一种具有强大的免疫抑制特性的真菌代谢物。它通过形成抑制钙调神经磷酸酶(蛋白磷酸酶 2B)的环孢菌素A−亲环蛋白复合物来抑制 T 细胞受体的信号转导途径。抑制由白介素1α、脂多糖和TNFα诱导的一氧化氮合成。阻止线粒体释放细胞色素 c。
 

法律信息

VETRANAL is a registered trademark of Sigma-Aldrich Chemie GmbH
 
 

属性

等级

analytical standard

质量水平

100

产品线

VETRANAL®

保质期

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)

格式

neat

SMILES string

CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C

InChI

1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1

InChI key

PMATZTZNYRCHOR-CGLBZJNRSA-N

Gene Information

human ... PPIA(5478)

 

安全信息

象形图

Exclamation markHealth hazard

警示用语:

Danger

危险分类

Acute Tox. 4 Oral - Carc. 1B - Repr. 1B

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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