环孢霉素A [环孢素A, 环孢菌素A]，Cyclosporin A；from Tolypocladium inflatum, BioReagent, for molecular biology, ≥95%

图片 环孢霉素A [环孢素A, 环孢菌素A]，Cyclosporin A；from Tolypocladium inflatum, BioReagent, for molecular biology, ≥95%
别名：环胞霉素A；环胞素A；环胞菌素A；环孢多肽A；环孢灵；赛斯平；山地明；环孢素；新山地明；抗生素S7481F1；Antibiotic S 7481F1；Cyclosporine

Empirical Formula (Hill Notation): C62H111N11O12 CAS号: 59865-13-3 分子量: 1202.61 Beilstein: 3647785 MDL编号: MFCD00274558 PubChem化学物质编号: 24892440 NACRES: NA.52
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: C1832
CAS号: 59865-13-3
MDL号: MFCD00274558
签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √

说明

化学结构：肽
环孢霉素A是一种具有免疫抑制特性的真菌代谢产物。环孢菌素A是一种非极性环状寡肽，由真菌Tolypocladium inflatum产生。它是一种有效的免疫抑制剂，主要影响T淋巴细胞。

一般描述

Chemical structure: peptide
Cyclosporin A is a fungal metabolite with immunosuppressive properties. Cyclosporin A is a non-polar cyclic oligopeptide produced by the fungus Tolypocladium inflatum. It is a potent immunosuppressive agent, affecting primarily T-lymphocytes.
 

应用

Cyclosporin A was suitable for:
  • Using in in vivo Neovascularization Assay, to subcutaneously inject the mice daily for suppressing the immune response.
  • Measuring the multiple drug resistance transporter activity in putative cancer stem/progenitor cells.
  • mRNA transcription studies
  • analytical standard

生化/生理作用

一种具有强大的免疫抑制特性的真菌代谢物。它通过形成抑制钙调神经磷酸酶（蛋白磷酸酶 2B）的环孢菌素A−亲环蛋白复合物来抑制 T 细胞受体的信号转导途径。抑制由白介素1α、脂多糖和TNFα诱导的一氧化氮合成。阻止线粒体释放细胞色素 c。
Cyclosporin A has been shown to inhibit the functioning of several nuclear proteins involved in T-cell activation at the level of mRNA transcription. It forms a complex with its intracellular receptor cyclophilin, which can then bind to calcineurin, a Ca2+ - and calmodulin-dependent protein phosphatase, inhibiting its enzymatic activity. It was found to suppress the replication of hepatitis C virus genome in cultured hepatocytes.
 
 

属性

生物来源

Tolypocladium inflatum

质量水平

300

等级

for molecular biology

产品线

BioReagent

测定

≥95%

形式

powder

溶解性

dichloromethane: 9.80-10.20 mg/mL, clear, colorless to faintly yellow

抗生素抗菌谱

fungi

作用机制

enzyme | inhibits

储存温度

2-8°C

SMILES string

CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C

InChI

1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1

InChI key

PMATZTZNYRCHOR-CGLBZJNRSA-N

Gene Information

human ... PPIA(5478)

 

安全信息

象形图

Exclamation markHealth hazard
GHS07,GHS08

警示用语：

Danger

危险分类

Acute Tox. 4 Oral - Carc. 1B - Repr. 1B

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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