sevenspikes.themes.common.filters
sevenspikes.themes.common.closemenu

环孢霉素A [环孢素A, 环孢菌素A],Cyclosporin A;from Tolypocladium inflatum, BioReagent, for molecular biology, ≥95%

别名:环孢多肽A;环孢灵;环孢霉素A;环胞霉素A;赛斯平;山地明;环孢素;新山地明;Antibiotic S 7481F1;Cyclosporine

CAS号 59865-13-3 经验分子式(希尔表示法) C62H111N11O12 分子量 1202.61 Beilstein/REAXYS Number 3647785 MDL number MFCD00274558 PubChem Substance ID 24892440 NACRES NA.52
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): C1832
CAS号: 59865-13-3
MDL号: MFCD00274558
增值税发票 √ 免费送货 √ 订货电话:010-68689484
HK$2,697.98

产品描述

General description

Chemical structure: peptide

Cyclosporin A is a fungal metabolite with immunosuppressive properties. Cyclosporin A is a non-polar cyclic oligopeptide produced by the fungus Tolypocladium inflatum. It is a potent immunosuppressive agent, affecting primarily T-lymphocytes.

Application

Cyclosporin A was suitable for:

• Using in in vivo Neovascularization Assay, to subcutaneously inject the mice daily for suppressing the immune response.[5]
• Measuring the multiple drug resistance transporter activity in putative cancer stem/progenitor cells.[6]
• mRNA transcription studies
• analytical standard

包装

5, 10 mg in glass bottle

Biochem/physiol Actions

具有强效免疫抑制性的真菌代谢物。它通过形成抑制钙调磷酸酶(蛋白磷酸酶 2B)的环孢菌素 A-亲环蛋白络合物来抑制 T 细胞受体信号转导通路。抑制通过白介素 1α、脂多糖和TNFα 诱导的一氧化氮合成。能够阻断细胞色素 c 从线粒体的释放。

Cyclosporin A has been shown to inhibit the functioning of several nuclear proteins involved in T-cell activation at the level of mRNA transcription.[2] It forms a complex with its intracellular receptor cyclophilin, which can then bind to calcineurin, a Ca2+ - and calmodulin-dependent protein phosphatase, inhibiting its enzymatic activity.[4][7][3] It was found to suppress the replication of hepatitis C virus genome in cultured hepatocytes.[1]

性质

Quality Level300
biological sourceTolypocladium inflatum
gradefor molecular biology
product lineBioReagent
assay≥95%
formpowder
solubilitydichloromethane: 9.80-10.20 mg/mL, clear, colorless to faintly yellow
Mode of actionenzyme | inhibits
antibiotic activity spectrumfungi
storage temp.2-8°C
SMILES stringCC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C
InChI1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1
InChI keyPMATZTZNYRCHOR-CGLBZJNRSA-N
Gene Informationhuman ... PPIA(5478)


安全信息

符号
信号词 Danger
危害声明 H302 - H350 - H360FD
危害码 (欧洲) T
风险声明 (欧洲) 45-60-22
安全声明 (欧洲) 53-45
RIDADR NONH for all modes of transport
WGK德国 WGK 3
RTECS GZ4120000
商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 190 | 欧洲Eur. ≥ 66 | 東京Tokyo ≥ 82 | 香港与北京 ≥ 55
商品标签