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环孢霉素A [环孢素A, 环孢菌素A]，Cyclosporin A；from Tolypocladium inflatum, BioReagent, for molecular biology, ≥95%

别名：环孢多肽A；环孢灵；环孢霉素A；环胞霉素A；赛斯平；山地明；环孢素；新山地明；Antibiotic S 7481F1；Cyclosporine

CAS号 59865-13-3 经验分子式（希尔表示法） C62H111N11O12 分子量 1202.61 Beilstein/REAXYS Number 3647785 MDL number MFCD00274558 PubChem Substance ID 24892440 NACRES NA.52

制造商品牌: 西格玛 Sigma-Aldrich

货号（SKU）: C1832

CAS号: 59865-13-3

MDL号: MFCD00274558

增值税发票 √ 免费送货 √ 订货电话：010-68689484

目录价.SKU-Variant

5mg
10mg [+HK$1,928.82]

HK$2,697.98

数量:

产品描述

General description

Chemical structure: peptide

Cyclosporin A is a fungal metabolite with immunosuppressive properties. Cyclosporin A is a non-polar cyclic oligopeptide produced by the fungus Tolypocladium inflatum. It is a potent immunosuppressive agent, affecting primarily T-lymphocytes.

Application

Cyclosporin A was suitable for:

• Using in in vivo Neovascularization Assay, to subcutaneously inject the mice daily for suppressing the immune response.^[5]
• Measuring the multiple drug resistance transporter activity in putative cancer stem/progenitor cells.^[6]
• mRNA transcription studies
• analytical standard

包装

5, 10 mg in glass bottle

Biochem/physiol Actions

具有强效免疫抑制性的真菌代谢物。它通过形成抑制钙调磷酸酶（蛋白磷酸酶 2B）的环孢菌素 A-亲环蛋白络合物来抑制 T 细胞受体信号转导通路。抑制通过白介素 1α、脂多糖和TNFα 诱导的一氧化氮合成。能够阻断细胞色素 c 从线粒体的释放。

Cyclosporin A has been shown to inhibit the functioning of several nuclear proteins involved in T-cell activation at the level of mRNA transcription.^[2] It forms a complex with its intracellular receptor cyclophilin, which can then bind to calcineurin, a Ca2+ - and calmodulin-dependent protein phosphatase, inhibiting its enzymatic activity.^[4]^[7]^[3] It was found to suppress the replication of hepatitis C virus genome in cultured hepatocytes.^[1]

性质

Quality Level	300
biological source	Tolypocladium inflatum
grade	for molecular biology
product line	BioReagent
assay	≥95%
form	powder
solubility	dichloromethane: 9.80-10.20 mg/mL, clear, colorless to faintly yellow
Mode of action	enzyme \| inhibits
antibiotic activity spectrum	fungi
storage temp.	2-8°C
SMILES string	CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C
InChI	1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1
InChI key	PMATZTZNYRCHOR-CGLBZJNRSA-N
Gene Information	human ... PPIA(5478)

安全信息

符号

GHS07,GHS08

信号词 Danger

危害声明 H302 - H350 - H360FD

警示性声明 P201 - P301 + P312 + P330 - P308 + P313

个人防护装备 Eyeshields, Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

危害码 (欧洲) T

风险声明 (欧洲) 45-60-22

安全声明 (欧洲) 53-45

RIDADR NONH for all modes of transport

WGK德国 WGK 3

RTECS GZ4120000

商品规格

属性名称	属性值
储存温度 Storage temp.	2-8°C冷藏
全球实时库存 Availability √	美国St. Louis ≥ 190 \| 欧洲Eur. ≥ 66 \| 東京Tokyo ≥ 82 \| 香港与北京 ≥ 55

商品标签

热门标签

环孢霉素A [环孢素A, 环孢菌素A]，Cyclosporin A；from Tolypocladium inflatum, BioReagent, for molecular biology, ≥95%

产品描述

General description

Application

包装

Biochem/physiol Actions

性质

安全信息

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