Chemical structure: peptide
Cyclosporin A is a fungal metabolite with immunosuppressive properties. Cyclosporin A is a non-polar cyclic oligopeptide produced by the fungus Tolypocladium inflatum. It is a potent immunosuppressive agent, affecting primarily T-lymphocytes.
Cyclosporin A was suitable for:
• Using in in vivo Neovascularization Assay, to subcutaneously inject the mice daily for suppressing the immune response.
• Measuring the multiple drug resistance transporter activity in putative cancer stem/progenitor cells.
• mRNA transcription studies
• analytical standard
5, 10 mg in glass bottle
具有强效免疫抑制性的真菌代谢物。它通过形成抑制钙调磷酸酶（蛋白磷酸酶 2B）的环孢菌素 A-亲环蛋白络合物来抑制 T 细胞受体信号转导通路。抑制通过白介素 1α、脂多糖和TNFα 诱导的一氧化氮合成。能够阻断细胞色素 c 从线粒体的释放。
Cyclosporin A has been shown to inhibit the functioning of several nuclear proteins involved in T-cell activation at the level of mRNA transcription. It forms a complex with its intracellular receptor cyclophilin, which can then bind to calcineurin, a Ca2+ - and calmodulin-dependent protein phosphatase, inhibiting its enzymatic activity. It was found to suppress the replication of hepatitis C virus genome in cultured hepatocytes.