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玉米赤霉酮,Zearalanone [ZEA];≥98% (TLC)

别名:;2,4-二羟基-6-(10-羟基-6-氧代十一烷基)苯甲酸 μ-内酯;2,4-Dihydroxy-6-(10-hydroxy-6-oxoundecyl)benzoic acid μ-lactone

Empirical Formula (Hill Notation): C18H24O5 CAS号: 5975-78-0 分子量: 320.38 MDL编号: MFCD00135821 PubChem化学物质编号: 24902160 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): Z0167
CAS号: 5975-78-0
MDL号: MFCD00135821
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说明

玉米赤霉烯酮 (ZEA) 或 F-2 毒素是一种非甾体雌激素真菌毒素,由各种镰刀菌属物种产生。 Fusarium graminearum 被认为是玉米赤霉烯酮的主要生产者。 通常见于霉变干草、高水分玉米、收获前感染的玉米等。

玉米赤霉烯酮被认为会引起猪的外阴阴道炎和雌激素反应。

一般描述

Zearalanone (ZEA) or F-2 toxin, a nonsteroidal estrogenic mycotoxin is produced by various Fusarium species. Fusarium graminearum is considered as the primary producer of zearalanone. It is usually seen in moldy hay, high-moisture corn, corn infected before harvest etc.
 

应用

Zearalanone has been used:
  • as mycotoxin to study its effects on the histology of ovaries in pre-pubertal bitches
  • as a mycotoxin to investigate its influence on selected immunological, haematological and biochemical indexes in bitches
  • as a standard to develop calibration curves in order to study its effects on progesterone and 17β-estradiol concentrations in peripheral blood and body weights of pre-pubertal female Beagle dogs
  • as a standard to develop calibration curves to study its level of intoxication in women with neoplastic lesions in the reproductive tract
 

生化/生理作用

Zearalanone is believed to cause vulvovaginitis and estrogenic responses in swine.
 
 

属性

质量水平

200

无菌性

non-sterile

测定

≥98% (TLC)

形式

powder

溶解性

methanol: 9.80-10.20 mg/mL, clear, colorless

运输

ambient

储存温度

−20°C

SMILES string

C[C@H]1CCCC(=O)CCCCCc2cc(O)cc(O)c2C(=O)O1

InChI

1S/C18H24O5/c1-12-6-5-9-14(19)8-4-2-3-7-13-10-15(20)11-16(21)17(13)18(22)23-12/h10-12,20-21H,2-9H2,1H3/t12-/m0/s1

InChI key

APJDQUGPCJRQRJ-LBPRGKRZSA-N

Gene Information

rat ... Ar(24208)

 

安全信息

象形图

Exclamation markHealth hazard

警示用语:

Warning

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 60 | 欧洲Eur. ≥ 21 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 10