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渥曼青霉素,Wortmannin, (PI3 Kinase inhibitor);≥95% (HPLC)

KY 12420;沃氏篮酶素;奥特曼宁;CAS号 19545-26-7 经验分子式(希尔表示法) C23H24O8 分子量 428.43 Beilstein/REAXYS Number 67676 MDL number MFCD00133927 eCl@ss: 32160405 NACRES: NA.41
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): 12-338
CAS号: 19545-26-7
MDL号: MFCD00133927
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说明

一般描述

Wortmannin, a fungal metabolite, is a cell-permeable, irreversible inhibitor of phosphatidylinositol 3 kinase (PI3 Kinase) with an IC50 of 5nM. It blocks the catalytic activity of PI3-Kinase without affecting upstream signaling events such as insulin receptor tyrosine kinase activity. Wortmannin also inhibits the activities of myosin light chain kinase and PI4-Kinase at concentrations a hundred times higher than those required to inhibit PI3-Kinase.
Wortmannin 是一种真菌代谢物,是一种细胞渗透性的、不可逆的磷脂酰肌醇 3 激酶 (PI3 Kinase) 抑制剂,IC50 为 5nM。 它阻断 PI3-激酶的催化活性,而不影响上游信号事件,如胰岛素受体酪氨酸激酶活性。 Wortmannin 还抑制肌球蛋白轻链激酶和 PI4-激酶的活性,其浓度比抑制 PI3-激酶所需的浓度高一百倍。
 

生化/生理作用

Protein Target: PI3Kγ
Target Sub-Family: PI3K/PI4K
Inhibitor Type: Kinase
 

质量

Routinely evaluated by kinase assay.
Purity: ≥95% by HPLC.
Molecular Formula: C23H24O8
Molecular Weight: 428.4
 

外形

1mg of lyophilized powder packaged under inert gas. White to off-white powder.
 

储存及稳定性

Protect from light. Stable for 2 years as supplied at -20°C. Following reconstitution aliquot and store at -20°. The DMSO/ethanol stock solutions are stable for 1-3 months at -20°C.
 

法律信息

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
 

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
 

属性

质量水平

100

测定

≥95% (HPLC)

mfr. no.

Upstate®

应用

activity assay: suitable (kinase)

NCBI登记号

UniProt登记号

运输

wet ice

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32
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