淀粉样蛋白β蛋白片段1-42 [大鼠β-淀粉样多肽]，β-Amyloid Peptide (1-42), Rat

Predominant peptide found in the brain of patients with Alzheimer’s Disease and Down’s Syndrome. Promotes down-regulation of Bcl-2 and upregulation of Bax expression in neurons.

β-Amyloid Peptide (Aβ) is the main constituent in both senile plaques and diffuse deposits in Alzheimer′s diseased brains. Under appropriate conditions, the soluble amyloid peptides aggregate into the fibrils associated with the disease state. It has proposed that Aβ peptide may increase the sensitivity of neurons to oxidative damage by downregulating expression of bcl-2, a key anti-apoptotic protein and upregulating of bax expression, a protein known to induce cell death.

 

在阿尔茨海默病和唐氏综合症患者的大脑中发现的主要肽。 促进神经元中 Bcl-2 的下调和 Bax 表达的上调。
β-淀粉样肽 (Aβ) 是老年斑和阿尔茨海默病大脑中弥漫性沉积物的主要成分。 在适当的条件下，可溶性淀粉样肽聚集成与疾病状态相关的原纤维。 有人提出，Aβ 肽可能通过下调 bcl-2（一种关键的抗凋亡蛋白）的表达和上调 bax 表达（一种已知可诱导细胞死亡的蛋白质）来增加神经元对氧化损伤的敏感性。

 

250 μg in Plastic ampoule

 

Toxicity: Standard Handling (A)

 

H-Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH

 

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Kang, J., et al. 1987. Nature 325, 733.

 

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