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沙帕色替,Sapanisertib [INK128 MLN0128];≥99% (HPLC)

别名:5-(4-氨基-1-异丙基-1H-吡唑并[3,4-d]嘧啶-3-基)苯并[d]恶唑-2-胺;INK-128;3-(2-amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

CAS:1224844-38-5;分子式:C15H15N7O;分子量:309.33;MDL:MFCD22124893
制造商品牌: BSZH 科学公司
货号(SKU): S06075
CAS号: 1224844-38-5
MDL号: MFCD22124893
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¥1,764.07

产品描述

产品可溶于DMSO(60mg/ml at 25°C)和乙醇(2mg/ml at 25°C)

Application

一种TORC1/2抑制剂,IC50:1 nM。也是具有潜在抗肿瘤活性的raptor-mTOR(TOR复合体1或TORC1)和.or-mTOR(TOR复合体2或TORC2)的抑制剂。

Sapanisertib is a TORC1/2 inhibitor, is also an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity. TORC1/2 inhibitor INK128 binds to and inhibits both TORC1 and TORC2 complexes of mTOR, which may result in tumor cell apoptosis and a decrease in tumor cell proliferation. TORC1 and 2 are upregulated in some tumors and play an important role in the PI3K/Akt/mTOR signaling pathway, which is frequently dysregulated in human cancers.

Sapanisertib是TORC1 / 2抑制剂,也是具有潜在抗肿瘤活性的raptor-mTOR(TOR复合物1或TORC1)和rictor-mTOR(TOR复合物2或TORC2)的口服生物利用抑制剂。 TORC1 / 2抑制剂INK128结合并抑制mTOR的TORC1和TORC2复合物,这可能导致肿瘤细胞凋亡和肿瘤细胞增殖减少。 TORC1和2在某些肿瘤中上调,并在PI3K / Akt / mTOR信号通路中起重要作用,而PI3K / Akt / mTOR信号通路在人类癌症中经常失调。

性质

Iupac Name3-(2-amino-1,3-benzoxazol-5-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Inchi Code1S/C15H15N7O/c1-7(2)22-14-11(13(16)18-6-19-14)12(21-22)8-3-4-10-9(5-8)20-15(17)23-10/h3-7H,1-2H3,(H2,17,20)(H2,16,18,19)
Inchi KeyGYLDXIAOMVERTK-UHFFFAOYSA-N


安全信息

符号 
GHS07  GHS07
信号词 Warning
危害声明 H302
警示性声明 P301 + P312 + P330
RIDADR NONH for all modes of transport
WGK德国 WGK 3
商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16
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