Silychristin is one of 3 flavonolignan isomers in Silymarin mixture, isolated from the fruits of Silybum Sarianum, also known as milk thistle. Silymarin is one of the most widely used phytochemicals due to its extensive therapeutic properties in ancient and modern times. Its hepatoprotective properties is very well established. It is known that Silymarin is an antioxidant and reduces free radical production. It inhibits toxin binding to hepatocytes and was shown to reduce liver injury caused by various agents such as acetaminophen, mycotoxins, bacterial toxins, alcohol and more. Various studies demonstrated protective effects of silymarin not only against hepatotoxic agents but also against nephrotoxic, cardiotoxic and neurotoxic agents. Furthermore, Silymarin was found to inhibit ROS formation and to protect pancreatic β-cells from oxidative stress mediated destruction. An inhibitory effect of silychristin (10-100μM) on the arachidonic acid metabolism by cyclooxygenase (COX) in blood platelets was discovered. This suggests Silychristin can serve as an antiplatelet and anti-inflammatory agent. Interestingly, Silychristin was also found to inhibit the thyroid hormone transporter (MCT8) with IC50 of approximately 100 nM in MDCK1 cells. This data indicate that Silychristin could block the uptake of thyroid hormone.
水飞蓟素是水飞蓟素混合物中的三种黄酮木脂素异构体之一，是从水飞蓟（Silybum Sarianum）的果实中分离的，也被称为蓟。水飞蓟素由于其在古代和现代的广泛治疗特性而成为使用最广泛的植物化学物质之一。它的保肝性能非常好。众所周知，水飞蓟素是一种抗氧化剂，可减少自由基的产生。它抑制毒素与肝细胞的结合，并显示出可以减少由对乙酰氨基酚，霉菌毒素，细菌毒素，酒精等多种物质引起的肝损伤。各种研究表明水飞蓟素不仅具有抗肝毒性的作用，而且还具有抗肾毒性，心脏毒性和神经毒性的作用。此外，发现水飞蓟素可抑制ROS的形成并保护胰腺β细胞免受氧化应激介导的破坏。发现了水飞蓟素（10-100μM）对血小板中环氧合酶（COX）对花生四烯酸代谢的抑制作用。这表明水飞蓟素可以用作抗血小板和抗炎药。有趣的是，还发现水飞蓟素可以抑制甲状腺激素转运蛋白（MCT8），在MDCK1细胞中的IC50约为100 nM。该数据表明水飞蓟素可能阻止甲状腺激素的摄取。
|solubility||ethanol: 5 mg/mL|