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氯霉素,Chloramphenicol;VETRANAL®, analytical standard, ≥98% (HPLC)

别名:氯霉素标准品;D-苏式-(-)-N-[α-(羟基甲基)-β-羟基-对硝基苯乙基]-2,2-二氯乙酰胺;(1R,2R)-N-[α-(羟基甲基)-β-羟基-对硝基苯乙基]-2,2-二氯乙酰胺;D-(-)-苏-1-对硝基苯基-2-二氯乙酰胺基-1,3-丙二醇;左旋霉素;左旋-苏-1-(对硝基苯基)-2-二氯乙酰氨基-1,3-丙二醇;D(−)-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-β-(4-nitrophenyl)ethyl]acetamide, D-(−)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol, D-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-4-nitrophenethyl]acetamide, Chloromycetin

CAS号 56-75-7 线性分子式 Cl2CHCONHCH(CH2OH)CH(OH)C6H4NO2 分子量 323.13 Beilstein/REAXYS Number 2225532 EINECS 编号 200-287-4 MDL number MFCD00078159 PubChem Substance ID 329753874 NACRES NA.24
货号(SKU): 31667
CAS号: 56-75-7
MDL号: MFCD00078159
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¥534.00

产品描述

General description

Chloramphenicol (CAP) is an antibiotic which was first isolated from Streptomyces venezuelae. It has a nitrobenzene moiety which may be responsible for aplastic anaemia.1 It is often used for bacterial selection in molecular biology applications at 10-20 μg/mL and as a selection agent for transformed cells containing chloramphenicol reistance genes.
This grade has the standard for Supelco MIP SPE cartridges. For more information request Supelco Literature T407075, T706024

Application

Chloramphenicol has been used as reference standard in the determination of the concentration of CAP residues in shrimp tissues using LC-MS technique[1] and also in frozen chicken samples (liver, kidney and muscle) using HPLC.[2]

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Mode of Action: Inhibits translation on the 50S ribosomal subunit at the peptidyltransferase step (elongation inhibition). Bacteriostatic.
Mode of Resistance: Acetylation by chloramphenicol acetyltransferase (cat gene).

Caution

Stock solutions should be stored at 2-8°C and are stable at 37°C for 5 days. Aqueous solutions are neutral and stable over a wide pH range, with 50% hydrolysis occurring after 290 days. Use of a borax buffered solution reduces this number to 14%. Solutions should be protected from light as photochemical decomposition results in a yellowing of the solution. Heating aqueous solutions at 115°C for 30 minutes results in a 10% loss of chloramphenicol.

Preparation Note

Stock solutions can be prepared directly in the vial at any recommended concentration. A solution at 50 mg/mL in ethanol yields a clear, very faint, yellow solution. Degradation of chloramphenicol in aqueous solution is catalyzed by general acids and bases. This rate of degradation is independent of the ionic strength and pH.

法律信息

VETRANAL is a registered trademark of Sigma-Aldrich Chemie GmbH

性质

Quality Level100
gradeanalytical standard
product lineVETRANAL®
assay≥98% (HPLC)
formneat
shelf lifelimited shelf life, expiry date on the label
application(s)HPLC: suitable
gas chromatography (GC): suitable
mp148-150 °C (lit.)
solubilityH2O: insoluble 100% (practically)
Featured IndustryClinical
Forensics and Toxicology
Pharmaceutical (small molecule)
formatneat
SMILES stringOC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+]([O-])=O
InChI1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1
InChI keyWIIZWVCIJKGZOK-RKDXNWHRSA-N


安全信息

符号
GHS08  GHS08
信号词 Warning
危害声明 H351
警示性声明 P201 - P308 + P313
危害码 (欧洲) T
风险声明 (欧洲) 45
安全声明 (欧洲) 53-45
RIDADR NONH for all modes of transport
WGK德国 WGK 3
RTECS AB6825000
商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 99 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 22 | 香港与北京 ≥ 32
商品标签