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氯霉素,Chloramphenicol;BioReagent, suitable for plant cell culture, ≥98.0%

别名:D-苏式-(-)-N-[α-(羟基甲基)-β-羟基-对硝基苯乙基]-2,2-二氯乙酰胺;(1R,2R)-N-[α-(羟基甲基)-β-羟基-对硝基苯乙基]-2,2-二氯乙酰胺;D-(-)-苏-1-对硝基苯基-2-二氯乙酰胺基-1,3-丙二醇;左旋霉素;左旋-苏-1-(对硝基苯基)-2-二氯乙酰氨基-1,3-丙二醇;D(−)-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-β-(4-nitrophenyl)ethyl]acetamide, D-(−)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol, D-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-4-nitrophenethyl]acetamide, Chloromycetin

CAS号 56-75-7 线性分子式 Cl2CHCONHCH(CH2OH)CH(OH)C6H4NO2 分子量 323.13 Beilstein/REAXYS Number 2225532 EINECS 编号 200-287-4 MDL number MFCD00078159 PubChem Substance ID 24892448 NACRES NA.76
货号(SKU): C1919
CAS号: 56-75-7
MDL号: MFCD00078159
增值税发票 √ 免费货运 [顺丰 联邦] √
¥432.00

产品描述

General description

Chemical structure: phenicole

包装

5, 25, 100 g in glass bottle

Application

Chloramphenicol is a synthetic antibiotic, isolated from strains of Streptomyces venezuelae. It is often used for bacterial selection in molecular biology applications at 10-20 μg/mL and as a selection agent for transformed cells containing chloramphenicol reistance genes.

Biochem/physiol Actions

Mode of Action: Inhibits translation on the 50S ribosomal subunit at the peptidyltransferase step (elongation inhibition). Bacteriostatic.
Mode of Resistance: Acetylation by chloramphenicol acetyltransferase (cat gene).

Caution

Stock solutions should be stored at 2-8°C and are stable at 37°C for 5 days. Aqueous solutions are neutral and stable over a wide pH range, with 50% hydrolysis occurring after 290 days. Use of a borax buffered solution reduces this number to 14%. Solutions should be protected from light as photochemical decomposition results in a yellowing of the solution. Heating aqueous solutions at 115°C for 30 minutes results in a 10% loss of chloramphenicol.

Preparation Note

Stock solutions can be prepared directly in the vial at any recommended concentration. A solution at 50 mg/mL in ethanol yields a clear, very faint, yellow solution. Degradation of chloramphenicol in aqueous solution is catalyzed by general acids and bases. This rate of degradation is independent of the ionic strength and pH.

Other Notes

Keep container tightly closed in a dry and well-ventilated place, Light sensitive. Storage class (TRGS 510): Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

性质

Quality Level200
product lineBioReagent
formpowder
application(s)cell culture | plant: suitable
impuritiesEndotoxin, tested
mp148-150 °C (lit.)
solubilityethanol: 50 mg/mL
Featured IndustryAgriculture
Mode of actionprotein synthesis | interferes
antibiotic activity spectrumGram-negative bacteria
Gram-positive bacteria
mycobacteria
mycoplasma
SMILES stringOC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+]([O-])=O
InChI1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1
InChI keyWIIZWVCIJKGZOK-RKDXNWHRSA-N
Gene Informationhuman ... CYP1A2(1544)


安全信息

符号
GHS08  GHS08
信号词 Warning
危害声明 H351
警示性声明 P201 - P308 + P313
危害码 (欧洲) T
风险声明 (欧洲) 45
安全声明 (欧洲) 53-45
RIDADR NONH for all modes of transport
WGK德国 WGK 3
RTECS AB6825000
商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 190 | 欧洲Eur. ≥ 66 | 東京Tokyo ≥ 82 | 香港与北京 ≥ 55
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