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氯化两面针碱,Nitidine chloride;≥97% (HPLC)

别名:2,3-Dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride, NSC 146397

Empirical Formula (Hill Notation): C21H18NO4 · Cl CAS号: 13063-04-2 分子量: 383.82 MDL编号: MFCD01659688 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML0610
CAS号: 13063-04-2
MDL号: MFCD01659688
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说明

氯化两面针碱是一种具有抗癌活性的天然产物。 其作用机制可能涉及多种途径。 已发现氯化尼替丁抑制拓扑异构酶 I 和拓扑异构酶 II,通过激活半胱天冬酶依赖性途径诱导细胞凋亡,抑制 c-Src/FAK 相关信号通路,抑制 Janus 激酶 2/STAT3 信号传导和 STAT3 依赖性靶标的表达 基因,包括细胞周期蛋白 D1、Bcl-xL 和 VEGF。 还发现氯化尼替丁具有抗疟疾活性。

生化/生理作用

Nitidine chloride is a natural product with anti-cancer activity. Its mechanism of action likely involves several pathways. Nitidine chloride has been found to inhibit topoisomerase I and topoisomerase II, induce cell apoptosis by activation of the caspase-dependent pathway, suppress c-Src/FAK associated signaling pathways and suppress Janus kinase 2/STAT3 signaling and the expression of STAT3-dependent target genes, including cyclin D1, Bcl-xL, and VEGF. Nitidine chloride has also been found to have anti-malaria activity.
 

特点和优势

This compound is featured on the CaspasesFak and JAKs pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
 
 

属性

质量水平

100

测定

≥97% (HPLC)

形式

powder

颜色

white to beige

溶解性

DMSO: 1 mg/mL, clear (warmed)

运输

wet ice

储存温度

−20°C

SMILES string

C[N+]1=CC2=CC(OC)=C(OC)C=C2C3=CC=C4C=C5C(OCO5)=CC4=C31.[Cl-]

InChI

1S/C21H18NO4.ClH/c1-22-10-13-7-17(23-2)18(24-3)8-15(13)14-5-4-12-6-19-20(26-11-25-19)9-16(12)21(14)22;/h4-10H,11H2,1-3H3;1H/q+1;/p-1

InChI key

QLDAACVSUMUMOR-UHFFFAOYSA-M

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 60 | 欧洲Eur. ≥ 21 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 10
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