茶碱，Theophylline；analytical standard, ≥99.0%, HPLC

别名：氨茶碱标准品；无水氨茶碱；1,3-二甲基黄嘌呤；2,6-二羟基-1,3-二甲基嘌呤；3,7-二氢-1,3-二甲基-1H-嘌呤-2,6-二酮；1,3-Dimethylxanthine, 2,6-Dihydroxy-1,3-dimethylpurine, 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione

CAS号 58-55-9 经验分子式（希尔表示法） C7H8N4O2 分子量 180.16 Beilstein/REAXYS Number 13463 EINECS 编号 200-385-7 MDL number MFCD00079619 PubChem Substance ID 24277677 NACRES NA.77

制造商品牌: BSZH

货号（SKU）: T0385

CAS号: 58-55-9

MDL号: MFCD00079619

签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √

目录价.SKU-Variant

¥1,260.00

数量:

产品描述

一种竞争性非选择性磷酸二酯酶抑制剂；

茶碱是一种茶生物碱，起非选择性PDE4抑制剂的作用。它可以在哮喘患者的支气管中引起平滑肌松弛。在增加的浓度下，茶碱可以起生殖毒性剂的作用，并通过使支持细胞失去功能而引起不育。随后，这会导致后期分化的生精细胞过早释放。磷酸二酯酶抑制剂；利尿剂心脏兴奋剂肌肉松弛剂哮喘药物。

Application

Theophylline has been used to study its effects on rat gene expression in the ubiquitin-proteasome pathway that regulates spermatogenesis and epididymal sperm quality. Theophylline has also been used as an internal standard for the measurement of plasma paracetamol levels in humans.

Biochem/physiol Actions

Theophylline is a tea alkaloid that functions as a nonselective PDE4 inhibitor. It can induce smooth muscle relaxation in the bronchiolae of asthma patients. At increased concentrations, theophylline can function as a reprotoxic agent and can cause infertility by incapacitating Sertoli cells. This subsequently causes the premature release of late differentiating spermatogenic cells^[2].

Phosphodiesterase inhibitor; diuretic; cardiac stimulant; muscle relaxant; asthma medication.

性质

grade	anhydrous
assay	≥99%
form	powder
color	white
solubility	H₂O: slightly soluble 8.3 mg/ml
	NH₄OH: 50 mg/ml, clear, colorless
	alcohol: 12.5 mg/ml
	chloroform: soluble 9.1 mg/ml
	0.1 M HCl: soluble
	0.1 M NaOH: soluble
	ammonium hydroxide: soluble
	aqueous base: soluble
	diethyl ether: slightly soluble
	dilute HCl: soluble
	dilute nitric acid: soluble
	ethanol: moderately soluble
originator	Forest Labs
SMILES string：	CN1C(=O)N(C)c2[nH]cnc2C1=O
InChI	1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9)
InChI key	ZFXYFBGIUFBOJW-UHFFFAOYSA-N

安全信息

符号

GHS06

信号词 Danger

危害声明 H301

警示性声明 P264 - P270 - P301 + P310 - P405 - P501

个人防护装备 dust mask type N95 (US), Eyeshields, Faceshields, Gloves

危害码 (欧洲) Xn

风险声明 (欧洲) 22

RIDADR UN 2811 6.1 / PGIII

WGK德国 WGK 1

RTECS XH3850000

商品规格

属性名称	属性值
储存温度 Storage temp.	常温阴凉避光
全球实时库存 Availability √	美国St. Louis ≥ 50 \| 欧洲Eur. ≥ 12 \| 東京Tokyo ≥ 20 \| 香港与北京 ≥ 50

商品标签 [tags]