茶碱是一种茶生物碱,起非选择性PDE4抑制剂的作用。 它可以在哮喘患者的支气管中引起平滑肌松弛。 在增加的浓度下,茶碱可以起生殖毒性剂的作用,并通过使支持细胞失去功能而引起不育。 随后,这会导致后期分化的生精细胞过早释放。磷酸二酯酶抑制剂; 利尿剂 心脏兴奋剂 肌肉松弛剂 哮喘药物。
Application
Theophylline has been used to study its effects on rat gene expression in the ubiquitin-proteasome pathway that regulates spermatogenesis and epididymal sperm quality. Theophylline has also been used as an internal standard for the measurement of plasma paracetamol levels in humans.
Biochem/physiol Actions
Theophylline is a tea alkaloid that functions as a nonselective PDE4 inhibitor. It can induce smooth muscle relaxation in the bronchiolae of asthma patients. At increased concentrations, theophylline can function as a reprotoxic agent and can cause infertility by incapacitating Sertoli cells. This subsequently causes the premature release of late differentiating spermatogenic cells[2].
Phosphodiesterase inhibitor; diuretic; cardiac stimulant; muscle relaxant; asthma medication.