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氟比洛芬,Flurbiprofen;Pharmaceutical Secondary Standard; Certified Reference Material

别名:氟比洛芬标准品;(±)-2-氟-α-甲基-4-联苯基乙酸;L-790330;(±)-2-Fluoro-α-methyl-4-biphenylacetic acid, L-790,330

线性分子式: C6H5C6H3(F)CH(CH3)CO2H CAS号: 5104-49-4 分子量: 244.26 EC 号: 225-827-6 MDL编号: MFCD00079303 PubChem化学物质编号: 329823420 NACRES: NA.24
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PHR1499
CAS号: 5104-49-4
MDL号: MFCD00079303
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¥1,553.16

说明

用于质量控制的制药二级标准,为制药实验室和制造商提供了一种方便且成本效益高的替代方案,以替代内部工作标准的制定。
氟比洛芬是一种非选择性、非甾体抗炎药(NSAID),广泛用于治疗类风湿性关节炎。它对春季角膜结膜炎、术后眼部炎症、疱疹性间质角膜炎、准分子激光屈光性角膜切除术和眼牙龈炎也有效。
氟比洛芬可用作通过各种分析技术测定药物制剂和生物样品中分析物的药物参考标准。
这些二级标准被认定为合格参考材料。这些适用于多种分析应用,包括但不限于药物释放测试、用于定性和定量分析的药物方法开发、食品和饮料质量控制测试以及其他校准要求。
氟比洛芬是一种环氧合酶(COX)抑制剂,是一种在前列腺素合成途径中负责花生四烯酸转化为前列腺素G2(PGG2)和PGG2转化为前列腺素H2(PGH2)的酶。这会减少导致炎症、疼痛、肿胀和发烧的前列腺素。氟比洛芬抑制COX-1和-2的活性。S对映体抑制前列腺素合成并具有抗炎和镇痛活性,而R对映体不抑制前列腺素合成,仅显示镇痛活性。

一般描述

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Flurbiprofen is a non-selective, non-steroidal anti-inflammatory drug (NSAID) that is widely used against rheumatoid arthritis. It is also effective against vernal keratoconjunctivitis, post-operative ocular inflammation, herpetic stromal keratitis, excimer laser photorefractive keratectomy and ocular gingivitis.
 

应用

Flurbiprofen may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and biological samples by various analytical techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
 

生化/生理作用

Fluibiprofen is a cyclooxygenase (COX) inhibitor, which is an enzyme responsible for the conversion of arachidonic acid to prostaglandin G2 (PGG2) and PGG2 to prostaglandin H2 (PGH2) in the prostaglandin synthesis pathway. This decreases the prostaglandins which cause inflammation, pain, swelling and fever. Flurbiprofen inhibits the activity of both COX-1 and -2. The S enantiomer inhibits prostaglandin synthesis and has both anti-inflammatory and analgesic activity, while the R enantiomer does not inhibit prostaglandin synthesis and displays only analgesic activity.
 

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
 

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
 

附注

To see an example of a Certificate of Analysis for this material enter LRAA3047 in the slot below. This is an example certificate only and may not be the lot that you receive.
 
 

属性

等级

certified reference material
pharmaceutical secondary standard

质量水平

300

Agency

traceable to Ph. Eur. F0285200
traceable to USP 1285750

CofA

current certificate can be downloaded

包装

pkg of 500 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

110-112 °C (lit.)

application(s)

pharmaceutical (small molecule)

格式

neat

储存温度

2-30°C

SMILES string

CC(C(O)=O)c1ccc(c(F)c1)-c2ccccc2

InChI

1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)

InChI key

SYTBZMRGLBWNTM-UHFFFAOYSA-N

Gene Information

human ... PTGS1(5742) , PTGS2(5743)

 

安全信息

象形图

Skull and crossbones

警示用语:

Danger

危险声明

危险分类

Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 55 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 8 | 香港与北京 ≥ 10
商品标签 [tags]