毛地黄皂苷，Digitonin [Digitin]；Used as non-ionic detergent

图片 毛地黄皂苷，Digitonin [Digitin]；Used as non-ionic detergent
别名：Digitin；一种非离子洗涤剂；洋地黄皂苷；毛地黄皂甙；毛地黄叶苷；地芰脱皂苷

Empirical Formula (Hill Notation): C56H92O29 CAS号: 11024-24-1 分子量: 1229.31 Beilstein: 78654 EC 号: 234-255-6 MDL编号: MFCD00077729 PubChem化学物质编号: 24893429 NACRES: NA.25
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: D141
CAS号: 11024-24-1
MDL号: MFCD00077729
签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √

说明

一般描述

Digitonin is a saponin obtained from foxglove. This non-ionic detergent has a head-tail structure. The bulky sugar headgroup of digitonin comprises two galactose, two glucose, and a xylose.
 

应用

Digitonin已用于一项对从腹水肿瘤细胞中分离线粒体过程进行评估的研究中。 [1] 它还用于研究其对癌细胞中植物次生代谢物的细胞毒性的影响。 [2] 这种温和的非离子型洗涤剂可用于溶解受体并对细胞膜和核膜进行通透化处理。
Digitonin has been used along with permeabilization buffer for cyclic guanosine monophosphate-adenosine monophosphate (cyclic GMP-AMP) stimulation in cells.
 

生化/生理作用

Digitonin plays a key role in permeabilizing cell membranes. It is capable of lysing eukaryotic cells but not bacterial membranes. It is also used to solubilize membrane components. It helps to create pores by interacting specifically with cholesterol in the membrane. It is preferred in biotechnology due to its mild detergency. This membrane-active compound act with doxorubicin against multi-drug resistant cancer cells.
 

质量

制备不包括不溶于水的成分。
 
 

属性

质量水平

200

形式

powder

旋光性

[α]20/D −54°, c = 2.8 in methanol(lit.)

分子量

micellar avg mol wt 70,000

聚集数

60

CMC

<0.5 mM (20-25°C)

mp

230-240 °C (dec.) (lit.)

溶解性

H2O: ~5 % (w/v) (solubilized by heating to 95 °C - 98 °C and then cooling to room temp.)

SMILES string

C[C@@]12[C@]([C@@H]3C)([H])[C@](O[C@]34CC[C@@H](C)CO4)([H])[C@@H](O)[C@@]1([H])[C@@](CC[C@]5([H])[C@@]6(C[C@@H](O)[C@H](O[C@]([C@@H]([C@@H](O)[C@H]7O[C@@](O[C@H](CO)[C@@H](O)[C@@H]8O[C@@](OC[C@@H](O)[C@@H]9O)([H])[C@@H]9O)([H])[C@@H]8O[C@@](O[C@H](CO)[C@H

InChI

1S/C56H92O29/c1-19-7-10-56(75-17-19)20(2)31-45(85-56)37(67)32-22-6-5-21-11-26(24(61)12-55(21,4)23(22)8-9-54(31,32)3)76-50-42(72)39(69)44(30(16-60)80-50)81-53-48(47(36(66)29(15-59)79-53)83-49-40(70)33(63)25(62)18-74-49)84-52-43(73)46(35(65)28(14-58)78-52)82-51-41(71)38(68)34(64)27(13-57)77-51/h19-53,57-73H,5-18H2,1-4H3/t19-,20+,21+,22-,23+,24-,25-,26-,27-,28-,29-,30-,31+,32-,33+,34-,35+,36-,37+,38+,39-,40-,41-,42-,43-,44+,45-,46+,47+,48-,49+,50-,51+,52+,53+,54-,55+,56-/m1/s1

InChI key

UVYVLBIGDKGWPX-KUAJCENISA-N

 

安全信息

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险声明

H301 - H373

预防措施声明

P301 + P310 + P330 - P314

危险分类

Acute Tox. 3 Oral - STOT RE 2

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

商品规格
属性名称属性值
储存温度 Storage temp.常温阴凉避光
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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