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橙皮油内酯 [橙皮油素],Auraptene;phyproof® Reference Substance, ≥90.0% (HPLC)

别名:奥拉普汀;7-[[(2E)-3,7-二甲基-2,6-辛二烯-1-基]氧基]-2H-1-苯并吡喃-2-酮;7-香叶氧基香豆素;Aurapten, 7-[[(2E)-3,7-dimethyl-2,6-octadien-1-yl]oxy]-2H-1-benzopyran-2-one, 7-Geranyloxycoumarin

Empirical Formula (Hill Notation): C19H22O3 CAS号: 495-02-3 分子量: 298.38 MDL编号: MFCD00075948
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PHL82481
CAS号: 495-02-3
MDL号: MFCD00075948
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说明

橙皮油内酯是一种雌激素受体调节剂,也可作为 ACAT 抑制剂。 它在几种异种移植物和化学诱导的小鼠肿瘤模型中显示出抗肿瘤作用。 橙皮油内酯在癌细胞系中诱导细胞凋亡并具有抗增殖作用。 它对 PPAR 具有激动作用,并通过抑制 ACAT (IC50 = 4 uM) 干扰脂质和胆固醇的产生。

一般描述

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
 

生化/生理作用

Auraptene is an estrogen receptor modulator that also acts as an ACAT inhibitor. It displays anti-tumor effects in several xenograft and chemically-induced murine tumor models. Auraptene induces apoptosis and is anti-proliferative in cancer cell lines. It has agonistic properties against PPARs, and interferes with lipid and cholesterol production by inhibiting ACAT (IC50 = 4 uM).
 

法律信息

phyproof is a registered trademark of PhytoLab GmbH & Co. KG
 
 

属性

等级

primary reference standard

产品线

phyproof® Reference Substance

测定

≥90.0% (HPLC)

形式

solid

manufacturer/tradename

PhytoLab

储存温度

2-8°C

SMILES string

C\C(C)=C\CC\C(C)=C\COc1ccc2C=CC(=O)Oc2c1

InChI

1S/C19H22O3/c1-14(2)5-4-6-15(3)11-12-21-17-9-7-16-8-10-19(20)22-18(16)13-17/h5,7-11,13H,4,6,12H2,1-3H3/b15-11+

InChI key

RSDDHGSKLOSQFK-RVDMUPIBSA-N

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16
商品标签 [tags]