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橙皮油内酯 [橙皮油素],Auraptene;≥98% (HPLC)

别名:奥拉普汀;7-[[(2E)-3,7-二甲基-2,6-辛二烯-1-基]氧基]-2H-1-苯并吡喃-2-酮;7-香叶氧基香豆素;Aurapten, 7-[[(2E)-3,7-dimethyl-2,6-octadien-1-yl]oxy]-2H-1-benzopyran-2-one, 7-Geranyloxycoumarin

Empirical Formula (Hill Notation): C19H22O3 CAS号: 495-02-3 分子量: 298.38 MDL编号: MFCD00075948 PubChem化学物质编号: 329771062
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): A9861
CAS号: 495-02-3
MDL号: MFCD00075948
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说明

橙皮油内酯 (7-香叶氧基香豆素) 是一种异戊烯氧基香豆素,在自然界中大量存在。 它由几种植物物种生产,例如芸香科和伞形科(伞形科)。

橙皮油内酯 (7-香叶氧基香豆素) 具有抗氧化、抗菌、抗炎和抗肿瘤活性。橙皮油内酯是一种雌激素受体调节剂,也可作为 ACAT 抑制剂。 它在几种异种移植物和化学诱导的小鼠肿瘤模型中显示出抗肿瘤作用。 橙皮油内酯在癌细胞系中诱导细胞凋亡并具有抗增殖作用。 它对 PPAR 具有激动作用,并通过抑制 ACAT (IC50 = 4 uM) 干扰脂质和胆固醇的产生。

一般描述

Auraptene (7-geranyloxycoumarin) is a prenyloxycoumarin, that is abundantly present in nature. It is produced by several plant species, such as Rutaceae and Umbeliferae (Apiaceae) families.
 

生化/生理作用

Auraptene (7-geranyloxycoumarin) possesses anti-oxidant, anti-bacterial, anti-inflammatory and anti-tumor activities.
Auraptene is an estrogen receptor modulator that also acts as an ACAT inhibitor. It displays anti-tumor effects in several xenograft and chemically-induced murine tumor models. Auraptene induces apoptosis and is anti-proliferative in cancer cell lines. It has agonistic properties against PPARs, and interferes with lipid and cholesterol production by inhibiting ACAT (IC50 = 4 uM).
 

特点和优势

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
 
 

属性

质量水平

100

测定

≥98% (HPLC)

形式

powder

颜色

white to off-white

溶解性

DMSO: >20 mg/mL

储存温度

−20°C

SMILES string

C\C(C)=C\CC\C(C)=C\COc1ccc2C=CC(=O)Oc2c1

InChI

1S/C19H22O3/c1-14(2)5-4-6-15(3)11-12-21-17-9-7-16-8-10-19(20)22-18(16)13-17/h5,7-11,13H,4,6,12H2,1-3H3/b15-11+

InChI key

RSDDHGSKLOSQFK-RVDMUPIBSA-N

 

安全信息

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16
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