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槐果碱,Sophocarpine;≥95% (HPLC)

别名:SC, 13,14-Didehydromatridin-15-one, (-)-Sophocarpine; Empirical Formula (Hill Notation): C15H22N2O CAS号: 6483-15-4 分子量: 246.35 MDL编号: MFCD00274555
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SML2422
CAS号: 6483-15-4
MDL号: MFCD00274555
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¥532.23

说明

槐果碱是一种天然产物,被发现具有抗炎、抗癌和抗病毒活性。 槐果碱在小鼠异种移植模型中具有活性。 它通过下调 miR-21 的表达来抑制头颈部鳞状细胞癌的生长。 Sophocarpine 还被证明可以通过抑制 IFNg/STAT1 通路来保护小鼠免受某种形式的肝炎的侵害。

生化/生理作用

Sophocarpine is a natural product found to have anti-inflammatory, anti-cancer, and antiviral activity. Sophocarpine was active in an mouse xenograft model. It inhibited growth of head and neck squamous cell carcinomas by downregulation of miR-21 expression. Sophocarpine was also shown to protecs mice from a form of hepatitis by inhibiting the IFNg/STAT1 pathway.
 
 

属性

生物来源

Sophora alopecuroides

测定

≥95% (HPLC)

形式

powder

旋光性

[α]/D -26 to -35°, c = 0.5 in ethanol

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear

储存温度

−20°C

InChI

1S/C15H22N2O.BrH/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14;/h1,7,11-13,15H,2-6,8-10H2;1H/t11-,12+,13+,15-;/m0./s1

InChI key

NBBQEIQEBNYSFK-PUILLJIJSA-N

 

安全信息

象形图

Skull and crossbones

警示用语:

Danger

危险声明

危险分类

Acute Tox. 3 Oral

储存分类代码

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 1

商品规格
属性名称属性值
储存温度 Storage temp.-20°C低温冷冻
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16