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木兰花碱,Magnoflorine;≥98% (HPLC)

别名:(6aS)-2,10-dimethoxy-6,6-dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-6-ium-1,11-diol; Empirical Formula (Hill Notation): C20H24NO4 CAS号: 2141-09-5 分子量: 342.41 MDL编号: MFCD09031380 PubChem化学物质编号: 329824978 NACRES: NA.25
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): SMB00377
CAS号: 2141-09-5
MDL号: MFCD09031380
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说明

Magnoflorine 是一种次生代谢产物,是一种具有季阿吗啡构型的生物碱。它可以在许多草本植物的根、根茎、茎、树皮或种子中找到,例如 Caulophyllum thalictroides(蓝升麻)、Arisolochai bractateate、P. amurense、S. acutum、Tinospora crispa、Coptidis rhizome 等。蓝升麻根和根茎中总生物碱的 65%。它也被称为thalictrine和escholine。

Magnoflorin 已被用于测试其对分离的小鼠子宫平滑肌组织和分离的 Mus musculus 远端结肠平滑肌组织条的收缩作用。

Magnoflorine 具有多种生化和药理学特性,例如抗氧化、抗炎、免疫调节、抗糖尿病、抗真菌、心血管保护和神经心理学。它也可作为 α-酪氨酸酶抑制剂。它有助于增加由脂多糖 (LPS) 诱导的促炎反应。它通过抑制胃癌进展胃癌细胞异种移植小鼠模型发挥抗肿瘤、抗癌活性。

一般描述

Magnoflorine is a secondary metabolite and an alkaloid with a quaternary aporphine configuration. It can be found in roots, rhizomes, stems, barks, or seeds of many herbal plants such as Caulophyllum thalictroides (blue cohosh), Arisolochai bracteateP. amurenseS. acutumTinospora crispaCoptidis rhizome, etc. Magnoflorine constitutes approximately 65 % of the total alkaloids in roots and rhizomes of blue cohosh. It is also known as thalictrine and escholine.
 

应用

Magnoflorin has been used to test its contractile effects on isolated mouse uterine smooth muscle tissues and on isolated strips of Mus musculus distal colon smooth muscle tissues.
 

生化/生理作用

Magnoflorine possesses several biochemical and pharmacological properties such as antioxidant, anti-inflammatory, immunomodulatory, anti-diabetic, anti-fungal, cardiovascular protective, and neuropsychological. It also acts as an α-tyrosinase inhibitor. It helps to increase pro-inflammatory responses induced by lipopolysaccharide (LPS). It exerts antitumor, anti-cancer activities by inhibiting gastric cancer progression gastric cancer cell xenograft mouse model.
 
 

属性

质量水平

200

测定

≥98% (HPLC)

形式

powder

储存温度

2-8°C

SMILES string

OC1=C(OC)C=C2CC[N+](C)(C)[C@@]3([H])CC4=CC=C(OC)C(O)=C4C1=C32

InChI

1S/C20H23NO4/c1-21(2)8-7-12-10-15(25-4)20(23)18-16(12)13(21)9-11-5-6-14(24-3)19(22)17(11)18/h5-6,10,13H,7-9H2,1-4H3,(H-,22,23)/p+1/t13-/m0/s1

InChI key

YLRXAIKMLINXQY-ZDUSSCGKSA-O

 

安全信息

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 55 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 8 | 香港与北京 ≥ 10