替卡西林二钠盐，Ticarcillin disodium salt；Potency (anhydrous basis): >800 µg/mg

图片 替卡西林二钠盐，Ticarcillin disodium salt；Potency (anhydrous basis): >800 µg/mg
别名：一种新型革兰氏阴性菌抗生素；替卡西林钠盐；羧噻吩青霉素钠-棒酸钾；特美汀；替门汀；替卡西林-克拉维酸钾；羧噻吩青霉素-棒酸钾；(2S,5R,6R)-6-[[(2R)-Carboxy-3-thienylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid disodium salt

CAS号 4697-14-7 经验分子式（希尔表示法） C15H14N2Na2O6S2 分子量 428.39 MDL number MFCD07787410 PubChem Substance ID 24900306 NACRES NA.85
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: T5639
CAS号: 4697-14-7
MDL号: MFCD07787410
签订合同 √ 正规发票 √ 技术支持 √ 质量保障 √ 全程可追溯 √

说明

化学结构：ß-内酰胺
替卡西林是一种半合成抗生素，对许多革兰氏阳性和革兰氏阴性需氧和厌氧细菌具有广谱杀菌活性。它通常与克拉维酸盐联合使用，以提高其疗效。用于研究囊性纤维化儿童患者的适当剂量。
替卡西林是一种β-内酰胺类抗生素，通过抑制肽聚糖转肽酶，在肽聚糖交联水平上阻止细菌细胞壁生物合成。它来源于青霉素，在作用上类似于羧青霉素。替卡西林易被ß-内酰胺酶降解。
β-内酰胺类抗生素

一般描述

Chemical structure: ß-lactam
 

应用

Ticarcillin is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria. It is commonly used in combination with clavulanate in order to improve it′s efficacy. It is used to study appropriate dosing in pediatric patients who have cystic fibrosis.

生化/生理作用

Ticarcillin is a β-Lactam antibiotic that prevents bacterial cell wall biosynthesis at the level of peptidogylcan cross-linking by inhibiting peptidoglycan transpeptidases. It is derived from penicillin and is similar to carbenicillin in action. Ticarcillin is susceptible to degradation by ß-lactamases.
 

其他说明

β-Lactam antibiotic
Keep container tightly closed in a dry and well-ventilated place. Moisture sensitive. Keep in a dry place.
 
 

属性

生物来源

semisynthetic

质量水平

200

形式

powder or crystals

储存条件

(Keep container tightly closed in a dry and well-ventilated place. Moisture sensitive. Keep in a dry place.)

颜色

white to light yellow

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria

作用机制

cell wall synthesis | interferes

储存温度

2-8°C

SMILES string

[Na+].[Na+].CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](C([O-])=O)c3ccsc3)C(=O)N2[C@H]1C([O-])=O

InChI

1S/C15H16N2O6S2.2Na/c1-15(2)9(14(22)23)17-11(19)8(12(17)25-15)16-10(18)7(13(20)21)6-3-4-24-5-6;;/h3-5,7-9,12H,1-2H3,(H,16,18)(H,20,21)(H,22,23);;/q;2*+1/p-2/t7-,8-,9+,12-;;/m1../s1

InChI key

ZBBCUBMBMZNEME-QBGWIPKPSA-L

 

安全信息

象形图

Exclamation markHealth hazard
GHS07,GHS08

警示用语：

Danger

危险分类

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 2

个人防护装备

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 50 | 欧洲Eur. ≥ 12 | 東京Tokyo ≥ 20 | 香港与北京 ≥ 50
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