替加环素水合物，Tigecycline hydrate；≥98% (HPLC)

图片 替加环素水合物，Tigecycline hydrate；≥98% (HPLC)
别名：水合替加环素；Tigecyclin；9-叔丁基甘氨酰胺米诺环素水合物；9-t-Butylglycylamido-minocycline hydrate；TBG-MINO, Tygacil

Empirical Formula (Hill Notation): C29H39N5O8 · xH2O CAS号: 1229002-07-6 分子量: 585.65 (anhydrous basis) PubChem化学物质编号: 329823688 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: PZ0021
CAS号: 1229002-07-6
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说明

一般描述

Tigecycline is used to treat complicated skin and skin structure infections (cSSSI) and complicated intraabdominal infections.[1]
 

应用

TIGECYCLINE HYDRATE has been used:
  • for antibiotic susceptibility testing[2]
  • to study its effects on multiple nonsmall cell lung cancer (NSCLC) cell lines[3]
  • to evaluate its effects on the binding of fluoroquinolones to human serum albumin[4]
  • as a standard to investigate the penetration of tigecycline into cornea, aqueous humor and vitreous humor[5]

生化/生理作用

Tigecycline is a broad spectrum glycylcycline antibiotic. Tigecycline is bacteriostatic, that inhibits protein synthesis by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation. Tigecycline is active against resistant strains of gram-positive and gram-negative bacteria, avoiding the two most common mechanisms of resistance to the tetracycline antimicrobials: tetracycline efflux pump proteins and ribosomal protection proteins.
 

其他说明

This compound was developed by Pfizer for Immunology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.
To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
air sensitive
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
Pfizer is a registered trademark of Pfizer, Inc.
 
 

属性

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

旋光性

[α]/D -175 to -205°, c = 0.15 in methanol

manufacturer/tradename

Pfizer®

颜色

off-white to yellow-brown

溶解性

DMSO: ≥3 mg/mL (warmed)

创始人

Pfizer

储存温度

2-8°C

SMILES string

O.CN(C)[C@H]1[C@@H]2C[C@@H]3Cc4c(cc(NC(=O)CNC(C)(C)C)c(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)N(C)C

InChI

1S/C29H39N5O8.H2O/c1-28(2,3)31-11-17(35)32-15-10-16(33(4)5)13-8-12-9-14-21(34(6)7)24(38)20(27(30)41)26(40)29(14,42)25(39)18(12)23(37)19(13)22(15)36;/h10,12,14,21,31,36,38-39,42H,8-9,11H2,1-7H3,(H2,30,41)(H,32,35);1H2/t12-,14-,21-,29-;/m0./s1

InChI key

PMPLAEFBZIFHAR-KXLOKULZSA-N

 

安全信息

象形图

Exclamation markHealth hazard
GHS07,GHS08

警示用语：

Danger

危险声明

H319 - H360

危险分类

Eye Irrit. 2 - Repr. 1B

储存分类代码

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 20 | 欧洲Eur. ≥ 16 | 東京Tokyo ≥ 5 | 香港与北京 ≥ 20
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