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替加环素水合物,Tigecycline hydrate;≥98% (HPLC)

别名:Tigecyclin, 9-t-Butylglycylamido-minocycline hydrate, TBG-MINO, Tygacil

Empirical Formula (Hill Notation): C29H39N5O8 · xH2O CAS号: 1229002-07-6 分子量: 585.65 (anhydrous basis) PubChem化学物质编号: 329823688 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号(SKU): PZ0021
CAS号: 1229002-07-6
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¥1,930.00

说明

一般描述

Tigecycline is used to treat complicated skin and skin structure infections (cSSSI) and complicated intraabdominal infections.
 

应用

TIGECYCLINE HYDRATE has been used:
  • for antibiotic susceptibility testing
  • to study its effects on multiple nonsmall cell lung cancer (NSCLC) cell lines
  • to evaluate its effects on the binding of fluoroquinolones to human serum albumin
  • as a standard to investigate the penetration of tigecycline into cornea, aqueous humor and vitreous humor

包装

5, 25 mg in glass bottle
 

生化/生理作用

Tigecycline is a broad spectrum glycylcycline antibiotic. Tigecycline is bacteriostatic, that inhibits protein synthesis by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation. Tigecycline is active against resistant strains of gram-positive and gram-negative bacteria, avoiding the two most common mechanisms of resistance to the tetracycline antimicrobials: tetracycline efflux pump proteins and ribosomal protection proteins.
替加环素是一种广谱甘氨酰环素抗生素。 替加环素是抑菌的,它通过与细菌的 30S 核糖体亚基结合来抑制蛋白质合成,从而在原核翻译过程中阻止氨酰 tRNA 进入核糖体的 A 位点。 替加环素对革兰氏阳性和革兰氏阴性细菌的耐药菌株具有活性,可避免对四环素抗菌剂产生耐药性的两种最常见机制:四环素外排泵蛋白和核糖体保护蛋白。
 

特点和优势

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®Pfizer), a collection of 90 Pfizer-developed drugs and research tools. Click here to learn more.
 

其他说明

air sensitive
This compound was developed by Pfizer for Immunology research. To learn more about Sigma′s partnership with Pfizer and view other authentic, high-quality Pfizer compounds, visit sigma.com/bsm-pfizer.

To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

法律信息

Sold for research purposes under agreement from Pfizer Inc.
LOPAC is a registered trademark of Sigma-Aldrich Co. LLC
Pfizer is a registered trademark of Pfizer, Inc.
 

属性

测定

≥98% (HPLC)

形式

powder

旋光性

α/D -175 to -205°, c = 0.15 in methanol

mfr. no.

Pfizer®

颜色

off-white to yellow-brown

溶解性

DMSO: ≥3 mg/mL (warmed)

创始人

Pfizer

储存温度

2-8°C

SMILES string

O.CN(C)C@H1C@@H2CC@@H3Cc4c(cc(NC(=O)CNC(C)(C)C)c(O)c4C(=O)C3=C(O)C@2(O)C(=O)C(C(N)=O)=C1O)N(C)C

InChI

1S/C29H39N5O8.H2O/c1-28(2,3)31-11-17(35)32-15-10-16(33(4)5)13-8-12-9-14-21(34(6)7)24(38)20(27(30)41)26(40)29(14,42)25(39)18(12)23(37)19(13)22(15)36;/h10,12,14,21,31,36,38-39,42H,8-9,11H2,1-7H3,(H2,30,41)(H,32,35);1H2/t12-,14-,21-,29-;/m0./s1

InChI key

PMPLAEFBZIFHAR-KXLOKULZSA-N

 

安全信息

象形图

Exclamation markHealth hazard

警示用语:

Danger

危险声明

商品规格
属性名称属性值
储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 33 | 欧洲Eur. ≥ 27 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 16