曲格列酮，Troglitazone；≥98% (HPLC)

图片 曲格列酮，Troglitazone；≥98% (HPLC)
图片 曲格列酮，Troglitazone；≥98% (HPLC)
图片 曲格列酮，Troglitazone；≥98% (HPLC)
别名：5-[[4-[(3,4-二氢-6-羟基-2,5,7,8-四甲基-2H-1-苯并吡喃-2-基)甲氧基]苯基]甲基]-2,4-噻唑烷二酮； (±)-5-[4-[(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl]-2,4-thiazolidinedione, CS-045

Empirical Formula (Hill Notation): C24H27NO5S CAS号: 97322-87-7 分子量: 441.54 MDL编号: MFCD00878416 PubChem化学物质编号: 24724629 NACRES: NA.77
制造商品牌: 西格玛 Sigma-Aldrich
货号（SKU）: T2573
CAS号: 97322-87-7
MDL号: MFCD00878416
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说明

一般描述

Troglitazone is used to treat type 2 diabetes. It is associated with liver injury.[1] Troglitazone functions as an inducer of cytochrome3A.[2]
 

应用

Troglitazone has been used as a reagent in adipocyte differentiation medium.[3][4]
 

生化/生理作用

PPARγ agonist; anti-diabetic thiazolidinedione (TZD) with anti-inflammatory and anti-tumor activity; induces apoptosis via a p53 pathway.
 

特点和优势

This compound is featured on the Nuclear Receptors (PPARs) and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
 

制备说明

Studies using troglitazone have reported that it can increase AMP-activated protein kinase (pAMPK) and phosphorylated acetyl-CoA carboxylase in isolated rat extensor digitorum longus muscles1. Furthermore, analysis of troglitazone-mediated autophagy is reported to correlate with the stimulation of AMPK α2.
 
 

属性

质量水平

200

测定

≥98% (HPLC)

形式

powder

颜色

white to off-white

溶解性

DMSO: 20 mg/mL

创始人

Pfizer

SMILES string

Cc1c(C)c2OC(C)(CCc2c(C)c1O)COc3ccc(CC4SC(=O)NC4=O)cc3

InChI

1S/C24H27NO5S/c1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,30-21)12-29-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/h5-8,19,26H,9-12H2,1-4H3,(H,25,27,28)

InChI key

GXPHKUHSUJUWKP-UHFFFAOYSA-N

Gene Information

human ... PPARA(5465) , PPARG(5468)

 

安全信息

储存分类代码

11 - Combustible Solids

WGK

WGK 2

个人防护装备

Eyeshields, Gloves, type N95 (US)

商品规格
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储存温度 Storage temp.2-8°C冷藏
全球实时库存 Availability √美国St. Louis ≥ 30 | 欧洲Eur. ≥ 10 | 東京Tokyo ≥ 9 | 香港与北京 ≥ 30
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